| Type | Description |
|---|---|
| Definition | dedicator of cytokinesis 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-23 10:59:00 | We identified a novel candidate oncogenic DOCK5 variant confirmed using qRT-PCR in a separate primary tumor validation set. Loss- and gain-of-function experiments indicated that DOCK5 variant promoted proliferation, migration, and invasion of HPV-negative HNSCC cells, and patients with higher expression of DOCK5 variant showed decreased overall survival. | 29945995 |
| 2019-08-17 11:26:00 | Study combined biochemical and structural approaches to characterize the biochemical activity of human DOCK5DHR2 and its inhibition by small molecules C21, a small molecule that inhibits mouse Dock5 in cells and blocks bone degradation in mice models of osteoporosis, and CPYPP, which inhibits both DOCK5 and Trio. C21 uses intramolecular dynamics of DOCK5 and Rac1 to remodel the complex into an unproductive conformation. | 29089502 |
| 2017-09-02 10:45:00 | our work identifies DOCK5 as a key regulator of epithelial invasion and metastasis, and demonstrates that suppression of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac GTPases. | 27669437 |
| 2013-02-09 11:05:00 | the potential role of DOCK5 in human obesity | 22595969 |
| 2010-01-21 00:00:00 | along with DOCK1, DOCK5 is an important mediator of CrkII/CrkL regulation of Caco-2 spreading and migration on collagen IV. | 19004829 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DOCK5_HUMAN,
B9A015_HUMAN,
Q68DL4_HUMAN
UniprotKB:
Q9H7D0,
B9A015,
Q68DL4
UniParc:
UPI0000D49574,
UPI000041A0E3,
UPI0000160D8B,
UPI000022D4F3
EMBL:
CR749353,
CR627414,
BC137175,
KF458713,
KF510313,
BC011877,
BC041761,
KF458716,
AC091185,
BC137176,
AK024687,
AC041005,
AK126249
Ensembl:
ENSG00000147459
KO:
hsa:80005
|
| Nucleutide sequences |
EMBL-CDS:
CAH10503.1,
BAB14962.1,
AAH41761.2,
AAI37176.1,
AAH11877.1,
AAI37177.1,
BAC86503.1,
CAH18206.1
Ensembl_TRS:
ENST00000276440,
ENST00000481100,
ENST00000410074
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000276440,
ENSP00000429737,
ENSP00000387036
RefSeq:
NP_079216.4,
NP_001309739.1
|
| Others |
UniRef100:
UniRef100_B9A015,
UniRef100_Q9H7D0,
UniRef100_Q68DL4
UniRef90:
UniRef90_Q9H7D0,
UniRef90_H0Y7N4,
UniRef90_A0A2K5TVN5
UniRef50:
UniRef50_Q9H7D0,
UniRef50_A0A2K5TVN5,
UniRef50_H0Y7N4
UniGene:
Hs.195403
CCDS:
CCDS6047.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员