| Type | Description |
|---|---|
| Definition | SET domain containing 6, protein lysine methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 15:58:00 | MiR-411 inhibits gastric cancer proliferation and migration through targeting SETD6. | 31081088 |
| 2019-10-12 11:13:00 | Study demonstrates that SETD6 monomeric, dimeric and trimeric forms are stabilized by the methyl donor, S-adenosyl-l-methionine. SETD6 has auto-methylation activity at K39 and K179, which serves as the major auto-methylation sites with a moderate auto-methylation activity toward K372. Data support a model by which SETD6 auto-methylation and self-interaction positively regulate its enzymatic activity in vitro. | 30189201 |
| 2019-03-30 11:03:00 | During mitosis SETD6 binds and methylates PLK1 | 30622182 |
| 2018-12-22 11:18:00 | WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration | 30226578 |
| 2018-03-24 11:00:00 | Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. | 28973356 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SETD6_HUMAN
UniprotKB:
Q8TBK2
UniParc:
UPI000013F058,
UPI000013C779
EMBL:
AC009118,
BC022451,
AK024801,
AK290495
Ensembl:
ENSG00000103037
KO:
hsa:79918
|
| Nucleutide sequences |
EMBL-CDS:
AAH22451.1,
BAB15011.1,
BAF83184.1
Ensembl_TRS:
ENST00000310682,
ENST00000219315
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000310082,
ENSP00000219315
RefSeq:
XP_011521638.1,
NP_079136.2,
NP_001153777.1
|
| Others |
UniRef100:
UniRef100_Q8TBK2
UniRef90:
UniRef90_Q8TBK2
UniRef50:
UniRef50_Q8TBK2
UniGene:
Hs.731691
CCDS:
CCDS10798.1,
CCDS54013.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员