| Type | Description |
|---|---|
| Definition | ATPase family AAA domain containing 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-09-19 16:27:00 | ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork. | 32542338 |
| 2020-04-04 10:07:00 | ATAD5, a PCNA unloader, plays multiple functions at stalled forks including promoting its restart. ATAD5 depletion increases genomic instability upon hydroxyurea treatment in cultured cells and mice. ATAD5 recruits RAD51 to stalled forks in an ATR kinase-dependent manner by hydroxyurea-enhanced protein-protein interactions and timely removes PCNA from stalled forks for RAD51 recruitment. | 31844045 |
| 2017-02-18 10:56:00 | Report rare ATAD5 missense mutations may contribute to genetic susceptibility breast cancer and epithelial ovarian carcinoma. | 27045477 |
| 2015-05-30 12:36:00 | Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review] | 25795125 |
| 2014-08-09 11:34:00 | Elg1 has an important role in maintaining chromosome integrity by regulating PCNA levels on chromatin, thereby acting as a PCNA unloading factor. | 23937667 |
| Type | IDs |
|---|---|
| Synonymous | C17orf41, ELG1, FRAG1 |
| Gene |
UniProtKB-ID:
ATAD5_HUMAN
UniprotKB:
Q96QE3
UniParc:
UPI0000071E9E,
UPI0001D14728
EMBL:
AC127024,
AC130324,
BC015051,
AJ314648,
AL832103,
AK022797,
AY557611
Ensembl:
ENSG00000176208
KO:
hsa:79915
|
| Nucleutide sequences |
EMBL-CDS:
BAB14248.1,
AAT52049.1,
AAH15051.1,
CAC44537.2,
CAH10412.1
Ensembl_TRS:
ENST00000321990
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000313171
RefSeq:
NP_079133.3,
XP_011523571.1,
XP_011523576.1,
XP_011523575.1,
XP_011523572.1
|
| Others |
UniRef100:
UniRef100_Q96QE3
UniRef90:
UniRef90_Q96QE3
UniRef50:
UniRef50_Q96QE3
UniGene:
Hs.528902
CCDS:
CCDS11260.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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