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799 CALCR

799

CALCR

calcitonin receptor

protein-coding

Homo sapiens

基因描述

Type Description
Definition calcitonin receptor

研究结论

Date Results Publications
2020-01-18 11:16:00 CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility (Meta-Analysis) 31626518
2018-03-10 10:49:00 CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3. 28428082
2017-10-14 12:02:00 structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy 28437792
2017-07-29 10:51:00 Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2]. 28614667
2017-06-24 11:39:00 Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India. 28435134

名称对应

Type IDs
Synonymous CRT, CT-R, CTR, CTR1
Gene
UniProtKB-ID: CALCR_HUMAN, A0A0C4DG16_HUMAN
UniprotKB: P30988, A0A0C4DG16
UniParc: UPI000002A55B, UPI0000D4AD1F, UPI00004432C6, UPI00035BEEF0, UPI0000050446, UPI0000441EC7, UPI000002A55A
EMBL: U26553, AC003078, S77875, S77876, AK313996, AB022177, FN994995, AJ831406, U26554, AC005024, L00587, AB022178, AJ831407, X82466, BC075028, BC069611, CH471091, X69920, CH236949, AY430048, FN994996
Ensembl: ENSG00000004948
KO: hsa:799
Nucleutide sequences
EMBL-CDS: AAC50300.1, AAB83945.1, EAL24142.1, AAH69611.1, BAA86928.1, BAA86929.1, AAR06949.1, AAC50301.1, BAG36708.1, CBN80568.1, AAD14268.1, CAA57849.1, CAH40796.1, CBN80567.1, AAH75028.2, EAW76814.1, CAH40797.1, AAA35640.1, CAA49541.1
Ensembl_TRS: ENST00000415529, ENST00000423724, ENST00000394441, ENST00000426151
Protein sequencees
Ensembl_PRO: ENSP00000413179, ENSP00000391369, ENSP00000377959, ENSP00000389295
RefSeq: NP_001158209.2, NP_001158210.1, NP_001733.1
Others
UniRef100: UniRef100_A0A0C4DG16, UniRef100_P30988
UniRef90: UniRef90_P30988
UniRef50: UniRef50_P30988
UniGene: Hs.489127
CCDS: CCDS5631.1

全选

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