| Type | Description |
|---|---|
| Definition | transmembrane 4 L six family member 20 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 10:18:00 | Identification of residues critical for topology inversion of the transmembrane protein TM4SF20 through regulated alternative translocation. | 30808712 |
| 2017-09-02 13:56:00 | Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1. | 27499293 |
| 2016-08-19 13:25:00 | TM4SF20 is the first protein shown to undergo Regulated Alternative Translocation in response to ceramide. In the absence of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the ER lumen. This form blocks activation of CREB3L1, a membrane-bound transcription factor. In the presence of ceramide, the membrane topology of TM4SF20 is inverted. The inverted form stimulates CREB3L1 cleavage. | 27499293 |
| 2013-12-21 11:26:00 | TM4SF20 ancestral deletion predisposes carriers to a pediatric disorder of early language delay and cerebral white matter hyperintensities. | 23810381 |
| 2010-06-30 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 20479760 |
| Type | IDs |
|---|---|
| Synonymous | PRO994, SLI5, TCCE518 |
| Gene |
UniProtKB-ID:
T4S20_HUMAN
UniprotKB:
Q53R12
UniParc:
UPI000013E99B
EMBL:
BC137256,
AY358671,
BC137257,
AK026453,
BC035754,
AC097662
Ensembl:
ENSG00000168955
KO:
hsa:79853
|
| Nucleutide sequences |
EMBL-CDS:
AAI37257.1,
AAQ89034.1,
AAH35754.1,
AAI37258.1,
AAY24253.1,
BAB15488.1
Gene_ORFName:
UNQ518/PRO994
Ensembl_TRS:
ENST00000304568
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000303028
RefSeq:
XP_011510178.1,
NP_079071.2
|
| Others |
UniRef100:
UniRef100_Q53R12
UniRef90:
UniRef90_Q53R12
UniRef50:
UniRef50_Q53R12
UniGene:
Hs.156652
CCDS:
CCDS2466.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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