| Type | Description |
|---|---|
| Definition | euchromatic histone lysine methyltransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-29 12:46:00 | 9q34.3 microduplications lead to neurodevelopmental disorders through EHMT1 overexpression. | 31209758 |
| 2020-08-01 14:36:00 | Results show that EHMT1 is overexpressed in inhibitors high-grade serous ovarian carcinoma (HGSOC) cell lines and patient-derived ascites. Combined EHMT1/2 high expression level correlates with poor patient outcomes. Knockdown or inhibition of EHMT1/2 restores sensitivity suggesting their implication in Pduanyu37i resistance. | 31775874 |
| 2020-04-11 10:55:00 | The authors show that IFI16 is in complex with the H3K9 methyltransferase SUV39H1 and GLP and recruits them to the human herpesvirus 8 genome during de novo infection and latency. The resulting depositions of H3K9me2/me3 serve as a docking site for the heterochromatin-inducing HP1alpha protein leading into the IFI16-dependent epigenetic modifications and silencing of the virus lytic genes. | 31682228 |
| 2020-03-07 11:54:00 | Neuronal networks of Kleefstra syndrome patient-derived cells exhibit network bursting with a reduced rate, longer duration, and increased temporal irregularity compared to control networks. We show that these changes are mediated by upregulation of NMDA receptor (NMDAR) subunit 1 correlating with reduced deposition of the repressive H3K9me2 mark, the catalytic product of EHMT1, at the GRIN1 promoter. | 31666522 |
| 2019-08-24 11:07:00 | We report infantile onset Pulmonary hypertension (PH) and congenital heart disease despite early CHD repair in three unrelated children with Kleefstra syndrome with deletions at 9q34.3 and define a 1.24 Mb critical region containing 47 protein-coding RefSeq genes including EHMT1. | 30063093 |
| Type | IDs |
|---|---|
| Synonymous | EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D |
| Gene |
UniProtKB-ID:
EHMT1_HUMAN,
A0A1B0GV09_HUMAN
UniprotKB:
Q9H9B1,
A0A1B0GV09
UniParc:
UPI000013E50E,
UPI00006C0FB8,
UPI000194EC2D,
UPI0001F992C5,
UPI0004EFFC72
EMBL:
BC011608,
AB058779,
AL590627,
AL365502,
AK022941,
AB028932,
AL713772,
AL611925,
BC047504,
AY083210
Ensembl:
ENSG00000181090
KO:
hsa:79813
|
| Nucleutide sequences |
EMBL-CDS:
AAM09024.1,
AAH47504.1,
CAD28534.1,
BAB14321.1,
BAB47505.2,
AAH11608.2,
BAB56104.1
Ensembl_TRS:
ENST00000462484,
ENST00000460843,
ENST00000371394,
ENST00000637161
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000417980,
ENSP00000485945,
ENSP00000417328,
ENSP00000490328
RefSeq:
XP_011517333.1,
XP_011517323.1,
NP_079033.4,
XP_024303445.1,
XP_016870625.1,
XP_024303448.1,
NP_001138999.1,
XP_011517332.1,
XP_016870627.1,
NP_001341541.1,
NP_001341540.1,
XP_011517331.1,
XP_016870626.1,
XP_024303447.1,
NP_001341188.1,
XP_024303443.1,
XP_024303446.1,
XP_024303442.1,
XP_016870623.1,
XP_011517327.1,
XP_011517324.1,
XP_011517325.1,
NP_001341192.1,
XP_005266162.1,
XP_005266167.1,
XP_024303444.1
|
| Others |
UniRef100:
UniRef100_A0A1B0GV09,
UniRef100_Q9H9B1
UniRef90:
UniRef90_Q9H9B1
UniRef50:
UniRef50_Q9H9B1
UniGene:
Hs.495511
CCDS:
CCDS56595.1,
CCDS7050.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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