| Type | Description |
|---|---|
| Definition | multimerin 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:25:00 | Multimerin-2 maintains vascular stability and permeability. | 31422156 |
| 2019-03-16 12:52:00 | Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis | 30544909 |
| 2018-07-14 12:14:00 | Results provide evidence identifying MMRN2 as a key molecule in regulating endothelial cell (EC) function and demonstrate that, during the angiogenic stimulation, its expression is controlled both transcriptionally and post-translationally by MMP9 for efficient EC sprouting. | 28435016 |
| 2018-07-14 10:53:00 | Data identify MMRN2 as a specific ligand for CD93. CD93 and MMRN2 are co-expressed in the blood vessels of various tumors. Moreover, disruption of the CD93-MMRN2 interaction reduced endothelial cell adhesion and migration. Site-directed mutagenesis identified different residue hotspots either directly or indirectly involved in the binding and propose a molecular model in which the coiled-coil domain of MMRN2 is engaged. | 28912033 |
| 2017-11-26 01:40:00 | These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation | 28671670 |
| Type | IDs |
|---|---|
| Synonymous | EMILIN-3, EMILIN3, ENDOGLYX-1 |
| Gene |
UniProtKB-ID:
MMRN2_HUMAN
UniprotKB:
Q9H8L6
UniParc:
UPI000013F046
EMBL:
AC025268,
BC094744,
AK023527,
BC064415
Ensembl:
ENSG00000173269
KO:
hsa:79812
|
| Nucleutide sequences |
EMBL-CDS:
BAB14599.1,
AAH64415.1,
AAH94744.1
Ensembl_TRS:
ENST00000372027
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361097
RefSeq:
XP_005270210.1,
NP_079032.2
|
| Others |
UniRef100:
UniRef100_Q9H8L6
UniRef90:
UniRef90_Q9H8L6
UniRef50:
UniRef50_Q9H8L6
UniGene:
Hs.524479
CCDS:
CCDS7379.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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