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79666 PLEKHF2

79666

PLEKHF2

pleckstrin homology and FYVE domain containing 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition pleckstrin homology and FYVE domain containing 2

研究结论

Date Results Publications
2020-08-22 15:32:00 The C-terminal acidic motif of Phafin2 inhibits PH domain binding to phosphatidylinositol 3-phosphate. 32126233
2017-07-22 12:37:00 PtdIns(3)P binding to Phafin2 occurs with high affinity, triggering minor conformational changes in the protein. Taken together, these studies represent a platform for establishing the structural basis of Phafin2 molecular interactions and the role of the two potentially redundant PtdIns(3)P-binding domains of the protein in endomembrane compartments. 28152563
2014-09-13 11:19:00 These findings establish that lysosomal accumulation of Akt and Phafin2 is a critical step in the induction of autophagy via an interaction with phosphatidylinositol 3 phosphate. 24416124
2013-02-23 11:54:00 Phafin2 controls EGFR trafficking through early endosomes by facilitating endosome fusion in concert with EEA1. 22816767
2010-03-22 11:21:00 These results provide a vivid example that an endosome modulator, such as Phafin2, may control the cells' responses to the extracellular cues. 19995552

名称对应

Type IDs
Synonymous EAPF, PHAFIN2, ZFYVE18
Gene
UniProtKB-ID: PKHF2_HUMAN
UniprotKB: Q9H8W4
UniParc: UPI0000035DB0
EMBL: AL834473, AK023249, AF434819, BC011806
Ensembl: ENSG00000175895
KO: hsa:79666
Nucleutide sequences
EMBL-CDS: AAL30774.1, AAH11806.1, CAD39132.1, BAB14486.1
Ensembl_TRS: ENST00000315367, ENST00000519516
Protein sequencees
Ensembl_PRO: ENSP00000427792, ENSP00000322373
RefSeq: NP_078889.1
Others
UniRef100: UniRef100_Q9H8W4
UniRef90: UniRef90_Q9H8W4
UniRef50: UniRef50_Q9H8W4
UniGene: Hs.29724
CCDS: CCDS6267.1

全选

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研究热度

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