| Type | Description |
|---|---|
| Definition | rhomboid 5 homolog 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:30:00 | The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. | 32825187 |
| 2021-02-20 13:29:00 | iRhom2 in the pathogenesis of oral squamous cell carcinoma. | 32236893 |
| 2020-06-06 11:05:00 | Results revealed that cervical cancer (CC) tissues had higher levels of iRhom2 than adjacent normal tissues. Its increased expression was significantly associated with tumor stage, size, and parametrium invasion as well as poor outcomes. Cancer stage and iRhom2 expression were independent prognostic indicators of CC. Its knockdown in HeLa cells inhibited cell growth, disrupted the cell cycle, and promoted apoptosis. | 31661139 |
| 2020-03-28 10:13:00 | It seems likely that as the involvement of rhomboid 5 homolog 2 protein (iRhom2) IN human diseases is increasingly recognized, they will become the focus of pharmaceutical interest [Review]. | 30890028 |
| 2019-04-20 12:13:00 | FRMD8 promotes inflammatory and growth factor signaling by stabilizing the iRhom2/ADAM17 sheddase complex. | 29897336 |
| Type | IDs |
|---|---|
| Synonymous | RHBDL5, RHBDL6, TEC, TOC, TOCG, iRhom2 |
| Gene |
UniProtKB-ID:
RHDF2_HUMAN
UniprotKB:
Q6PJF5
UniParc:
UPI0000DBEF0D,
UPI0000578476
EMBL:
AK292166,
BC016034,
AY500247,
BC035829,
AC015802,
AK292135,
AK025994
Ensembl:
ENSG00000129667
KO:
hsa:79651
|
| Nucleutide sequences |
EMBL-CDS:
BAF84824.1,
BAB15310.1,
AAH16034.2,
AAS77567.1,
BAF84855.1,
AAH35829.1
Ensembl_TRS:
ENST00000591885,
ENST00000313080
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000466867,
ENSP00000322775
RefSeq:
XP_011523551.1,
XP_011523552.1,
NP_001363158.1,
XP_005257726.1,
NP_001363159.1,
XP_011523553.1,
NP_001363157.1,
NP_001005498.2,
NP_078875.4
|
| Others |
UniRef100:
UniRef100_Q6PJF5
UniRef90:
UniRef90_Q6PJF5
UniRef50:
UniRef50_Q6PJF5
UniGene:
Hs.464157
CCDS:
CCDS32744.1,
CCDS32743.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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