| Type | Description |
|---|---|
| Definition | neuregulin 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 10:38:00 | Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. | 29265764 |
| 2019-04-20 11:17:00 | Loss of zinc finger protein multitype 1 (Zfpm1) activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation. | 30611731 |
| 2017-11-25 15:09:00 | we observed the activation of Notch signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling. | 27926871 |
| 2017-06-24 10:58:00 | these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF-like ligand(s) activates the ErbB2/ErbB4 pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF family member requirements for an evolutionary conserved process. | 27846271 |
| 2016-05-28 11:12:00 | Notch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression | 26628092 |
| Type | IDs |
|---|---|
| Synonymous | wu:fm70e01 |
| Gene |
UniProtKB-ID:
A0A0R4IFE6_DANRE,
A0A0R4IBM0_DANRE,
A0A0R4IDP7_DANRE,
B3DK99_DANRE,
A0A1B4Z255_DANRE,
A0A0R4IPH3_DANRE
UniprotKB:
A0A0R4IFE6,
A0A0R4IBM0,
A0A0R4IDP7,
B3DK99,
A0A1B4Z255,
A0A0R4IPH3
UniParc:
UPI0004F478D2,
UPI0000F1F0BF,
UPI0001E9030C,
UPI0001766225,
UPI0001E9030B,
UPI0001E9030D
EMBL:
FJ593485,
BX537303,
BX321906,
BC163772,
CR855879,
LC126300,
CU459101
Ensembl:
ENSDARG00000104314
KO:
dre:796461
|
| Nucleutide sequences |
EMBL-CDS:
ACM45579.1,
AAI63772.1,
BAV53525.1
Ensembl_TRS:
ENSDART00000168885,
ENSDART00000163702,
ENSDART00000167706,
ENSDART00000167963,
ENSDART00000167054
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000132632,
ENSDARP00000131493,
ENSDARP00000132985,
ENSDARP00000134846,
ENSDARP00000137540
RefSeq:
NP_001038376.2,
XP_009298701.1,
XP_009298838.1,
XP_021334884.1,
XP_005155520.1,
XP_009299081.1,
XP_017213479.1,
NP_001264014.1,
NP_001264013.1,
XP_021334886.1,
XP_021334885.1,
XP_009298988.1,
NP_001264015.1
|
| Others |
UniRef100:
UniRef100_A0A0R4IBM0,
UniRef100_A0A0R4IFE6,
UniRef100_B3DK99,
UniRef100_A0A0R4IDP7,
UniRef100_A0A1B4Z255,
UniRef100_A0A0R4IPH3
UniRef90:
UniRef90_A0A0R4IFE6,
UniRef90_A0A0R4IBM0
UniRef50:
UniRef50_A0A0R4IFE6,
UniRef50_Q02297-6
UniGene:
Dr.133124
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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