A reference map of the human binary protein interactome.

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Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

Nat Commun     Robert Fragoza , Jishnu Das , Shayne D Wierbowski , Jin Liang , Tina N Tran , Siqi Liang , Juan F Beltran , Christen A Rivera-Erick , Kaixiong Ye , Ting-Yi Wang , Li Yao , Matthew Mort , Peter D Stenson , David N Cooper , Xiaomu Wei , Alon Keinan , John C Schimenti , Andrew G Clark , Haiyuan Yu

Architecture of the human interactome defines protein communities and disease networks.

Nature     Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper

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A proteome-scale map of the human interactome network.

Cell     Thomas Rolland , Murat Taşan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal

A Y2H-seq approach defines the human protein methyltransferase interactome.

Nat. Methods     Mareike Weimann , Arndt Grossmann , Jonathan Woodsmith , Ziya Özkan , Petra Birth , David Meierhofer , Nouhad Benlasfer , Taras Valovka , Bernd Timmermann , Erich E Wanker , Sascha Sauer , Ulrich Stelzl

Next-generation sequencing to generate interactome datasets.

Nat Methods     Haiyuan Yu , Leah Tardivo , Stanley Tam , Evan Weiner , Fana Gebreab , Changyu Fan , Nenad Svrzikapa , Tomoko Hirozane-Kishikawa , Edward Rietman , Xinping Yang , Julie Sahalie , Kourosh Salehi-Ashtiani , Tong Hao , Michael E Cusick , David E Hill , Frederick P Roth , Pascal Braun , Marc Vidal

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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

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