| Type | Description |
|---|---|
| Definition | RecQ protein-like 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 12:00:00 | Study has demonstrated the ATP-dependent helicase activity of Recql4 is not physiologically essential for murine embryonic development or adult homeostasis, cellular replication and physiological DNA damage repair. However, mutations that create truncating proteins are not tolerated. | 31276497 |
| 2016-03-26 11:52:00 | RECQL4 is essential for normal bone development. Animals with no Recql4 in bone cells did not develop osteosarcoma. | 25859855 |
| 2016-03-19 12:14:00 | findings show that RECQL4 is critical for skeletal development by modulating p53 activity in vivo. | 25556649 |
| 2015-02-21 10:17:00 | data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases | 24960165 |
| 2014-10-25 10:05:00 | dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to Rothmund-Thomson syndrome features in mice. | 24832598 |
| Type | IDs |
|---|---|
| Synonymous | RecQ4 |
| Gene |
UniProtKB-ID:
RECQ4_MOUSE,
A0A0R4J0J3_MOUSE
UniprotKB:
Q75NR7,
A0A0R4J0J3
UniParc:
UPI00000E6A17,
UPI0000576827,
UPI000035173C
EMBL:
AC156550,
AB175741,
AB039882,
AB042529
Ensembl:
ENSMUSG00000033762
KO:
mmu:79456
|
| Nucleutide sequences |
EMBL-CDS:
BAB32696.1,
BAD11131.1,
BAD14289.1
Ensembl_TRS:
ENSMUST00000036852
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000044363
RefSeq:
XP_006521610.1,
XP_017172293.1,
XP_006521611.1,
XP_006521609.1,
NP_478121.2
|
| Others |
UniRef100:
UniRef100_Q75NR7,
UniRef100_A0A0R4J0J3
UniRef90:
UniRef90_Q75NR7
UniRef50:
UniRef50_Q75NR7
UniGene:
Mm.18373
CCDS:
CCDS27588.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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