| Type | Description |
|---|---|
| Definition | iroquois homeobox 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:23:00 | Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects. | 32651404 |
| 2020-07-18 12:11:00 | Lifestyle modification may exert its effects on obesity through changes in the expression level of the FTO and IRX3 genes. However, FTO genotype plays a role in the extent of the effect of lifestyle changes on gene expression. | 31126299 |
| 2020-05-02 11:26:00 | Irx3 is required for preadipocyte identity and differentiation capacity. | 31751577 |
| 2019-12-21 10:17:00 | Promotion of IRX3 signalling or inhibition of IRX5 signalling could be a route towards differentiation therapy for Wilms tumour, in which WNT5A is a candidate molecule for enforced tubular maturation. | 30246301 |
| 2019-06-15 11:10:00 | Data show that hypothalamic Irx3 is down-regulated by prolonged fasting and by a high-fat diet. The hypothalamic inhibition of Irx3 results in increased body mass gain due to increased caloric intake and reduced energy expenditure accompanied by reduced BAT thermogenesis. Thus, Irx3 is abnormally regulated in diet-induced obesity, and further reducing its hypothalamic levels results in increased body mass. | 30522931 |
| Type | IDs |
|---|---|
| Synonymous | IRX-1, IRXB1 |
| Gene |
UniProtKB-ID:
IRX3_HUMAN
UniprotKB:
P78415
UniParc:
UPI000019745F
EMBL:
BC023667,
AY335943,
U90308,
AY335942
Ensembl:
ENSG00000177508
KO:
hsa:79191
|
| Nucleutide sequences |
EMBL-CDS:
AAQ16549.1,
AAB50006.1,
AAQ16548.1,
AAH23667.1
Ensembl_TRS:
ENST00000329734
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000331608
RefSeq:
NP_077312.2,
XP_005256196.1
|
| Others |
UniRef100:
UniRef100_P78415
UniRef90:
UniRef90_P78415
UniRef50:
UniRef50_P78415
UniGene:
Hs.499205
CCDS:
CCDS10750.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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