| Type | Description |
|---|---|
| Definition | BRCA1/BRCA2-containing complex subunit 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:13:00 | BRCC36 functions noncatalytically to promote antiviral response by maintaining protein stability. | 32673428 |
| 2020-10-31 13:13:00 | Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination. | 31866999 |
| 2020-08-12 13:02:00 | Cell lines and primary mouse cells with inactivation of BRCC3 had a higher sensitivity to doxorubicin. | 31576005 |
| 2020-02-22 12:30:00 | BRCC3 expressed in oligodendrocyte precursor cells in vitro is required for the oligodendrocyte lineage progression toward the mature stage. Lack of BRCC3 function could deteriorate demyelination at the lesion site. An increase in Lys63-linked ubiquitination levels induced by the deregulation of BRCC3 expression promotes the endosomal/lysosomal processing of myelin proteins. | 31184779 |
| 2020-01-18 11:48:00 | Here we show that in the BRCA1-A complex structure, ABRAXAS integrates the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor suppressor BRCA1 away from the break site. In the BRISC structure, ABRO1 binds SHMT2alpha, a metabolic enzyme enabling cancer growth in hypoxic environments, which we find prevents BRCC36 from binding and cleaving ubiquitin chains | 31253574 |
| Type | IDs |
|---|---|
| Synonymous | BRCC36, C6.1A, CXorf53 |
| Gene |
UniProtKB-ID:
BRCC3_HUMAN
UniprotKB:
P46736
UniParc:
UPI0000126C8F,
UPI000002A518,
UPI00017A77C7,
UPI0000E0C8F6,
UPI0000469E0A
EMBL:
AY438030,
AK298886,
BX293995,
BC002999,
AK299194,
S68015,
BC006540,
AK313544,
BX470111,
X64643
Ensembl:
ENSG00000185515
KO:
hsa:79184
|
| Nucleutide sequences |
EMBL-CDS:
AAR30498.1,
BAG60999.1,
BAG61237.1,
AAH02999.1,
BAG36320.1,
CAA45917.1,
AAH06540.1,
AAB29005.2
Ensembl_TRS:
ENST00000340647,
ENST00000369462,
ENST00000330045,
ENST00000369459
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000344103,
ENSP00000358474,
ENSP00000358471,
ENSP00000328641
RefSeq:
XP_005274808.1,
XP_016885327.1,
NP_001229569.1,
NP_001018065.1,
NP_077308.1
|
| Others |
UniRef100:
UniRef100_P46736
UniRef90:
UniRef90_P46736
UniRef50:
UniRef50_P46736
UniGene:
Hs.558537
CCDS:
CCDS56611.1,
CCDS56612.1,
CCDS56610.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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