| Type | Description |
|---|---|
| Definition | WD repeat domain 77 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:44:00 | WD Repeat Domain 77 Protein Regulates Translation of E2F1 and E2F3 mRNA. | 33020149 |
| 2020-04-04 11:47:00 | These results suggest that MEP50/PRMT5 is important for HH signal-induced GLI1 activation, especially in cancers. | 30675521 |
| 2019-04-27 11:29:00 | curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application. | 30392062 |
| 2019-04-13 11:42:00 | Deacetylation of WDR77 at Lys-3 and Lys-243 suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. | 30282801 |
| 2018-06-30 12:13:00 | A 3.7 A structure of PRMT5, solved in complex with regulatory binding subunit MEP50 (methylosome associated protein 50, WDR77, p44), by single particle (SP) cryo-Electron Microscopy (cryo-EM) using micrographs of particles that are visibly crowded and aggregated. The catalytic PRMT5 subunits form a core tetramer and the MEP50 subunits are arranged peripherally in complex with the PRMT5 N-terminal domain. | 29518110 |
| Type | IDs |
|---|---|
| Synonymous | HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50 |
| Gene |
UniProtKB-ID:
MEP50_HUMAN,
A0A024R0H7_HUMAN
UniprotKB:
Q9BQA1,
A0A024R0H7
UniParc:
UPI0000047AC6,
UPI00017A77A2
EMBL:
AK223189,
HM005667,
AK022860,
AB074171,
BC016946,
BC011778,
BC006477,
AB073603,
AK298179,
BC001679,
AF478464,
AY225316,
CH471122,
AL390195,
BC009411
Ensembl:
ENSG00000116455
KO:
hsa:79084
|
| Nucleutide sequences |
EMBL-CDS:
AAL79917.1,
BAD96909.1,
BAG60450.1,
AAP79114.1,
BAE45736.1,
AAH09411.1,
AAH06477.1,
AAH01679.1,
BAD38641.1,
AAH16946.1,
EAW56493.1,
BAG51128.1,
AAH11778.1,
EAW56494.1,
AEE61264.1
Gene_ORFName:
HKMT1069,
Nbla10071,
hCG_39991
Ensembl_TRS:
ENST00000235090
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000235090
RefSeq:
NP_001303993.1,
NP_077007.1,
NP_001303992.1,
NP_001303991.1
|
| Others |
UniRef100:
UniRef100_Q9BQA1
UniRef90:
UniRef90_Q9BQA1
UniRef50:
UniRef50_Q9BQA1
UniGene:
Hs.204773
CCDS:
CCDS835.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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