例如:"NBL1", "4681", "drought"
收藏
79053 ALG8

79053

ALG8

ALG8 alpha-1,3-glucosyltransferase

protein-coding

Homo sapiens

基因描述

Type Description
Definition ALG8 alpha-1,3-glucosyltransferase

研究结论

Date Results Publications
2020-06-13 12:01:00 analysis of genetic variants in ALG8 in patients with congenital disorders of glycosylation 30420707
2017-09-16 10:34:00 used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH and SEC63, to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8, GANAB, and SEC61B. Similarly to PRKCSH and SEC63, these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum. 28375157
2016-04-30 11:31:00 In ALG8-CDG, isoelectric focusing of transferrin in serum or plasma shows an abnormal sialotransferrin pattern. The diagnosis is confirmed by mutation analysis in ALG8; all patients reported so far had point mutations or small deletions 26066342
2014-09-27 10:50:00 We reviewed the clinical features in all nine previously reported patients diagnosed with ALG8-disorder of glycosylation with a special focus on their skin signs. 24555185
2012-07-28 10:42:00 Severe ALG8 congenital disorder of glycosylation(CDG-Ih) is associated with homozygosity for two novel missense mutations in exon 8 of ALG8 22306853

名称对应

Type IDs
Synonymous CDG1H, PCLD3
Gene
UniProtKB-ID: ALG8_HUMAN, A0A024R5K5_HUMAN
UniprotKB: Q9BVK2, A0A024R5K5
UniParc: UPI000013E5C8, UPI00004B2480
EMBL: BC001133, AP002520, KU178764, CH471076, AJ224875
Ensembl: ENSG00000159063
KO: hsa:79053
Nucleutide sequences
EMBL-CDS: CAA12176.1, AAH01133.1, EAW75050.1, EAW75048.1, ALQ34222.1, EAW75051.1
Gene_ORFName: HUSSY-02, hCG_1819356
Ensembl_TRS: ENST00000376156, ENST00000299626, ENST00000615266
Protein sequencees
Ensembl_PRO: ENSP00000365326, ENSP00000480742, ENSP00000299626
RefSeq: XP_011543554.1, XP_016873763.1, NP_001007028.1, NP_076984.2, XP_005274304.1
Others
UniRef100: UniRef100_Q9BVK2
UniRef90: UniRef90_Q9BVK2
UniRef50: UniRef50_Q9BVK2
UniGene: Hs.503368
CCDS: CCDS41692.1, CCDS8258.1

全选

{{proteinIndex+1}}
mRNA Protein UniprotKB Description
Refseq {{protein.nucleotideVersion}}

Ensembl: {{protein.nucleotideEnsembl}}

{{protein.proteinVersion}}

Ensembl: {{protein.proteinEnsembl}}

{{uniprot}}
Definition: {{{protein.definition}}}

Transcript Veriant:{{protein.transcriptVeriant}}

Status: {{protein.status}}

Location ( {{protein.positionStart}}..{{protein.positionEnd}} )

暂无数据

研究热度

热点单位
排名 科研单位 文献
{{affIndex+1}}

{{aff.value}}

{{aff.size}}

目前还没有研究热点单位

热点人员
排名 研究人员 文献
{{authorIndex+1}}

{{author.value}}

{{author.size}}

目前还没有研究热点人员