| Type | Description |
|---|---|
| Definition | SH3 and multiple ankyrin repeat domains 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-08-11 11:46:00 | Loss of scaffold proteins via knockdown of Shank1 or Shank2, but not Shank3, led to a reduction of the number but not the unitary response of AMPAR-containing synapses. Only when both Shank1 and Shank2 were knocked down, were both the number and the unitary response of active synapses reduced. This reduction was accompanied by a decrease in NMDAR-mediated synaptic response. | 29250591 |
| 2017-06-24 10:57:00 | SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. | 28263956 |
| 2016-02-06 10:14:00 | Upon depolarization with high K+, neither the intensity nor distribution of label for GKAP changed, but labeling intensity for Shank at the postsynaptic density increased to ~150% of controls. | 25775468 |
| 2014-08-16 10:14:00 | All three Shank mRNA isoforms are differentially expressed in the synaptic neuropil. | 24298140 |
| 2011-06-04 11:17:00 | this study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain. | 21376703 |
| Type | IDs |
|---|---|
| Synonymous | Shank1a, Spank1, Sstrip |
| Gene |
UniProtKB-ID:
SHAN1_RAT
UniprotKB:
Q9WV48
UniParc:
UPI000002B399,
UPI000013594D,
UPI000002B39B,
UPI0000376ABE,
UPI000002B39A
EMBL:
AF141904,
AF131951,
AF102855,
AF159046
Ensembl:
ENSRNOG00000019207
KO:
rno:78957
|
| Nucleutide sequences |
EMBL-CDS:
AAD04569.2,
AAF02498.1,
AAD29417.1,
AAD42975.1
Ensembl_TRS:
ENSRNOT00000044257,
ENSRNOT00000092327,
ENSRNOT00000026100
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000075838,
ENSRNOP00000039860,
ENSRNOP00000026100
RefSeq:
NP_113939.2,
XP_017445247.1,
XP_017445248.1,
XP_008757638.1,
XP_017445250.1,
XP_017445249.1
|
| Others |
UniRef100:
UniRef100_Q9WV48
UniRef90:
UniRef90_Q9WV48
UniRef50:
UniRef50_Q9WV48
UniGene:
Rn.225968
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员