| Type | Description |
|---|---|
| Definition | steroid 5 alpha-reductase 1 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-16 12:19:00 | Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice | 28493878 |
| 2017-07-01 10:36:00 | Exaggerated predisposition to metabolic disorders in female mice, compared with that seen in male mice, after disruption of 5alphaR1 suggests phenotypic changes may be underpinned by altered metabolism of glucocorticoids rather than androgens. | 27647861 |
| 2016-03-12 10:21:00 | the Srd5a1 gene modulates ethanol consumption in a sex-dependent manner that is also contingent upon ethanol access condition and concentration | 25416204 |
| 2016-03-12 10:04:00 | deletion of the Srd5a1 gene significantly decreased ethanol's anxiolytic effect in female mice, and chronic ethanol withdrawal severity was lower in female versus male mice | 25355320 |
| 2016-03-05 10:38:00 | transcription of srd5a1 in brain is regulated by environmental factor-induced cytosine methylation in the promoter region. | 26314512 |
| Type | IDs |
|---|---|
| Synonymous | 0610031P22Rik, 4930435F02Rik, S5AR 1, Srd5a-1 |
| Gene |
UniProtKB-ID:
S5A1_MOUSE,
Q8BUR8_MOUSE,
A0A0R4J136_MOUSE
UniprotKB:
Q68FF9,
Q8BUR8,
A0A0R4J136
UniParc:
UPI0000419EC9,
UPI000163D0F6,
UPI00000EA9DD
EMBL:
AK082819,
AC122484,
BC094503,
BC079863
Ensembl:
ENSMUSG00000021594
KO:
mmu:78925
|
| Nucleutide sequences |
EMBL-CDS:
AAH79863.1,
AAH94503.1,
BAC38634.1
Ensembl_TRS:
ENSMUST00000091514
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000089097
RefSeq:
XP_006517537.1,
XP_006517536.1,
NP_780492.2
|
| Others |
UniRef100:
UniRef100_Q8BUR8,
UniRef100_A0A0R4J136,
UniRef100_Q68FF9
UniRef90:
UniRef90_Q8BUR8,
UniRef90_P24008
UniRef50:
UniRef50_Q8BUR8,
UniRef50_P24008
UniGene:
Mm.451912,
Mm.483181
CCDS:
CCDS26624.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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