| Type | Description |
|---|---|
| Definition | adhesion G protein-coupled receptor A2 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-30 12:14:00 | experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS Epithelial Cells to promote angiogenesis and regulate the BBB. | 28803732 |
| 2017-08-12 10:20:00 | Gpr124 is an endothelial GPCR specifically required for endothelial Wnt signaling and BBB integrity under pathological conditions in adult mice. | 28288111 |
| 2015-09-26 10:40:00 | Vital role for GPR124 is potentiation of WNT7-induced canonical beta-catenin signaling with important implications for understanding and manipulating CNS-specific angiogenesis. | 25558062 |
| 2015-01-17 10:46:00 | Gpr124 functions as coactivator of Wnt7a- and Wnt7b-stimulated canonical Wnt signaling via Frizzled receptor and Lrp coreceptor and that Gpr124-stimulated signaling functions in concert with Norrin/Frizzled4 signaling to control CNS vascular development | 25373781 |
| 2011-07-02 11:23:00 | GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. | 21421844 |
| Type | IDs |
|---|---|
| Synonymous | 8430414O08Rik, 9530074E10Rik, Gpr124, Tem5, mKIAA1531 |
| Gene |
UniProtKB-ID:
AGRA2_MOUSE
UniprotKB:
Q91ZV8
UniParc:
UPI0001884496
EMBL:
BC138451,
AF378759,
BC138452
Ensembl:
ENSMUSG00000031486
KO:
mmu:78560
|
| Nucleutide sequences |
EMBL-CDS:
AAI38453.1,
AAI38452.1,
AAL11996.1
Ensembl_TRS:
ENSMUST00000033876
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033876
RefSeq:
NP_473385.2,
XP_006509286.3,
XP_006509285.3,
XP_006509287.3
|
| Others |
UniRef100:
UniRef100_Q91ZV8
UniRef90:
UniRef90_Q91ZV8
UniRef50:
UniRef50_Q96PE1
UniGene:
Mm.87046
CCDS:
CCDS22210.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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