| Type | Description |
|---|---|
| Definition | zona pellucida glycoprotein 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 12:26:00 | We identified loss-of-function pathogenic variants of ZP2 causing a structurally abnormal and dysfunctional zona pellucida, resulting in fertilization failure and female infertility | 29895852 |
| 2019-05-25 10:10:00 | Mutations in ZP1, ZP2, and ZP3 might affect the corresponding protein expression, secretion, and interaction, thus providing a mechanistic explanation for the phenotypes for female infertility. | 30810869 |
| 2017-08-12 12:12:00 | Mutations in ZP2 and ZP3 have dosage effects which can cause female infertility in humans. | 28646452 |
| 2014-08-23 10:53:00 | ZP2(51-149) sperm-binding domain is necessary for human gamete recognition and penetration through the zona pellucida. | 24934154 |
| 2014-02-25 11:20:00 | Studies indicate that eggs from mice lacking an ortholog of ZP2 do not contain a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts. | 23417405 |
| Type | IDs |
|---|---|
| Synonymous | ZPA, Zp-2 |
| Gene |
UniProtKB-ID:
ZP2_HUMAN
UniprotKB:
Q05996
UniParc:
UPI000013C45C,
UPI000050ED6E
EMBL:
BC096305,
M90366,
BC096306,
BC096304,
CH471228,
BC096307,
AF001550,
AK313003
Ensembl:
ENSG00000284588,
ENSG00000103310
KO:
hsa:7783
|
| Nucleutide sequences |
EMBL-CDS:
BAG35839.1,
EAW66859.1,
AAH96306.1,
AAA61335.1,
AAH96304.1,
AAH96307.1,
AAH96305.1,
AAB67599.1
Ensembl_TRS:
ENST00000638300,
ENST00000574002,
ENST00000640487,
ENST00000574091
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000458991,
ENSP00000491583,
ENSP00000460971,
ENSP00000492703
RefSeq:
NP_001363162.1,
NP_001363161.1,
NP_001363160.1,
NP_003451.1
|
| Others |
UniRef100:
UniRef100_Q05996
UniRef90:
UniRef90_Q05996
UniRef50:
UniRef50_Q05996
UniGene:
Hs.73982
CCDS:
CCDS10596.1,
CCDS73843.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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