| Type | Description |
|---|---|
| Definition | polymerase (DNA directed), theta |
| Date | Results | Publications |
|---|---|---|
| 2019-07-27 12:39:00 | DNA polymerase theta, the versatile mediator of microhomology-based repair of DNA double-strand breaks and stalled replication forks, is now revealed to be a member of an elite group of proteins known as annealing helicases. | 29215638 |
| 2017-12-30 10:56:00 | Poltheta;-helicase promotes chromosomal translocations by alternative nonhomologous end joining in mouse embryonic stem cells and also suppresses CRISPR-Cas9- mediated gene targeting by homologous recombination. Poltheta;-helicase activity facilitates the removal of RPA from resected double-strand breaks to allow their annealing and subsequent joining by alternative nonhomologous end joining. | 29058711 |
| 2017-12-30 10:41:00 | Classical non-homologous end-joining (cNHEJ) and polymerase theta-mediated end-joining (TMEJ) act both parallel and redundant in mouse embryonic stem cells and account for virtually all end-joining activity. | 29079701 |
| 2017-10-07 11:19:00 | Here, the authors discover that mammalian Poltheta; transfers nucleotides to the 3' terminus of DNA during alt-EJ in vitro and in vivo by oscillating between three different modes of terminal transferase activity: non-templated extension, templated extension in cis, and templated extension in trans. | 27311885 |
| 2017-09-02 11:53:00 | DNA polymerase theta mediates end joining repair of chromosome breaks and helps to sustain cell viability and genome stability by rescuing chromosome break repair when resection is misregulated or NHEJ is compromised. | 27453047 |
| Type | IDs |
|---|---|
| Synonymous | A430110D14Rik |
| Gene |
UniProtKB-ID:
DPOLQ_MOUSE,
Q80XB7_MOUSE
UniprotKB:
Q8CGS6,
Q80XB7
UniParc:
UPI00000E8E5A,
UPI000018D446
EMBL:
BC157900,
AY147862,
AC155254,
BC138360,
AC154763,
AY074936,
AK139505
Ensembl:
ENSMUSG00000034206
KO:
mmu:77782
|
| Nucleutide sequences |
EMBL-CDS:
AAN64234.1,
BAE24040.1,
AAI57901.1,
AAI38361.1,
AAL77225.1
Ensembl_TRS:
ENSMUST00000054034,
ENSMUST00000071452
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000059757,
ENSMUSP00000071396
RefSeq:
NP_084253.1,
XP_006522799.2,
NP_001152841.1,
XP_036016073.1,
XP_006522798.1
|
| Others |
UniRef100:
UniRef100_Q8CGS6
UniRef90:
UniRef90_Q8CGS6
UniRef50:
UniRef50_O75417
UniGene:
Mm.259114
CCDS:
CCDS49845.1,
CCDS28158.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员