| Type | Description |
|---|---|
| Definition | notum palmitoleoyl-protein carboxylesterase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 13:47:00 | Therapies targeting osteoblast-derived NOTUM may prevent nonvertebral fractures. | 31307226 |
| 2019-10-12 12:42:00 | results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues | 31292548 |
| 2018-06-02 10:36:00 | Notum influences mesenchymal cell differentiation by generating a barrier for Wnt ligands produced and secreted by airway epithelial cells to attenuate Wnt signaling. | 29428562 |
| 2017-09-30 10:28:00 | The findings support a significant role for NOTUM in modulating WNT signaling pathways that have pleiotropic effects on tooth and kidney development. | 26926082 |
| 2016-10-01 11:18:00 | Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. | 26517809 |
| Type | IDs |
|---|---|
| Synonymous | 5730593N15Rik |
| Gene |
UniProtKB-ID:
NOTUM_MOUSE
UniprotKB:
Q8R116
UniParc:
UPI0000195061,
UPI00001C4C78
EMBL:
BC025832,
AL663030
Ensembl:
ENSMUSG00000042988
KO:
mmu:77583
|
| Nucleutide sequences |
EMBL-CDS:
AAH25832.1
Ensembl_TRS:
ENSMUST00000106178,
ENSMUST00000106177
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000101783,
ENSMUSP00000101784
RefSeq:
XP_006534560.1,
NP_001369199.1,
XP_011247617.1,
NP_780472.3,
NP_001369198.1
|
| Others |
UniRef100:
UniRef100_Q8R116
UniRef90:
UniRef90_Q8R116
UniRef50:
UniRef50_Q8R116
UniGene:
Mm.32839
CCDS:
CCDS49007.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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