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7709 ZBTB17

7709

ZBTB17

zinc finger and BTB domain containing 17

protein-coding

Homo sapiens

基因描述

Type Description
Definition zinc finger and BTB domain containing 17

研究结论

Date Results Publications
2021-01-02 12:53:00 Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen. 33057331
2018-12-22 11:34:00 Because RPL23 is encoded by a target gene of c-Myc, the RPL23/Miz-1/c-Myc regulatory circuit provides a feedback loop that links efficient RPL23 expression with c-Myc's function to suppress Miz-1-induced Cdk inhibitors and thereby leads to apoptotic resistance in higher-risk myelodysplastic syndrome patients 28539603
2018-09-01 11:48:00 This study firstly associates ZBTB17 loss-of-function mutation with enhanced susceptibility to DCM in humans, which provides novel insight into the molecular mechanism underpinning DCM, implying potential implications for genetic counseling and personalized management of DCM 29445930
2018-08-25 11:23:00 These data suggest that MYC acts as a master coordinator that inversely modulates the impact of cell cycle and circadian clock on gene expression via its interaction with MIZ1. 27339797
2018-07-09 13:25:00 strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1/BCL6 and of Miz1/NAC1 are reported 25484205

名称对应

Type IDs
Synonymous MIZ-1, ZNF151, ZNF60, pHZ-67
Gene
UniProtKB-ID: ZBT17_HUMAN, Q53EM1_HUMAN
UniprotKB: Q13105, Q53EM1
UniParc: UPI00005054F0, UPI000050AA4B, UPI000013C9D2, UPI00020658C8
EMBL: BC126163, AK301896, AL355994, BC143965, M88369, AK223618, U20647, AL034555, Y09723
Ensembl: ENSG00000116809
KO: hsa:7709
Nucleutide sequences
EMBL-CDS: CAA70889.1, AAI26164.1, AAA61327.1, AAI43966.1, BAG63326.1, AAC50256.1, BAD97338.1
Ensembl_TRS: ENST00000537142, ENST00000375743, ENST00000375733
Protein sequencees
Ensembl_PRO: ENSP00000438529, ENSP00000364885, ENSP00000364895
RefSeq: XP_011540390.1, NP_001229813.1, NP_001274533.1, NP_001274532.1, XP_011540388.1, XP_011540387.1, XP_005246044.1, NP_003434.2, NP_001311067.1, XP_016857731.1, XP_011540389.1, NP_001311066.1, XP_005246043.1
Others
UniRef100: UniRef100_Q13105, UniRef100_Q53EM1
UniRef90: UniRef90_Q13105
UniRef50: UniRef50_Q13105
UniGene: Hs.433764
CCDS: CCDS55576.1, CCDS72712.1, CCDS165.1

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