| Type | Description |
|---|---|
| Definition | DDRGK domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 11:11:00 | Study shows that Ufbp1-mediated suppression of PERK has an essential function in the differentiation of naive B cells into plasma cells. In addition, Ufbp1 is upregulated downstream of IRE1alpha /XBP1 pathway to critically enforce the expansion of endoplasmic reticulum network and function of plasma cells. | 30842412 |
| 2018-12-22 10:09:00 | Study results provide evidence that DDRGK1 is essential for endoplasmic reticulum (ER) homeostasis regulation in both human cancer cells and mouse hematopoietic stem cells. Depletion of DDRGK1 activates apoptotic pathway by targeting the ER-stress sensor IRE1alpha. DDRGK1 regulates IRE1alpha protein stability via its interaction with the kinase domain of IRE1alpha. | 28128204 |
| 2016-06-04 11:44:00 | findings suggest that UFBP1, along with ASC1 and other ufmylation components, play pleiotropic roles in regulation of hematopoietic cell survival and differentiation via modulating ER homeostasis and erythroid lineage-specific gene expression | 26544067 |
| 2011-10-03 16:14:00 | These data suggest that UFM1-UFBP1 participate in preventing endoplasmic reticulum stress-induced apoptosis in protein secretory cells. | 21494687 |
| Type | IDs |
|---|---|
| Synonymous | 1110001I20Rik, 2600009E05Rik, AI326138, Ufbp1 |
| Gene |
UniProtKB-ID:
DDRGK_MOUSE
UniprotKB:
Q80WW9
UniParc:
UPI00001D4713
EMBL:
AK011170,
BC115617,
BC051541,
AL731707,
AL772162,
CH466519,
BC115616
Ensembl:
ENSMUSG00000068290
KO:
mmu:77006
|
| Nucleutide sequences |
EMBL-CDS:
EDL28284.1,
AAI15617.1,
AAI15618.1,
AAH51541.1,
BAB27444.1
Ensembl_TRS:
ENSMUST00000089559
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000086988
RefSeq:
NP_084108.1
|
| Others |
UniRef100:
UniRef100_Q80WW9
UniRef90:
UniRef90_Q80WW9
UniRef50:
UniRef50_Q80WW9
UniGene:
Mm.440063
CCDS:
CCDS38243.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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