| Type | Description |
|---|---|
| Definition | protease, serine 8 (prostasin) |
| Date | Results | Publications |
|---|---|---|
| 2019-05-11 13:07:00 | Genetic Prss8 deficiency caused colitis and an inflamed rectum at an early age and intestinal tumors at a late age, with increased intestinal cell proliferation and migration but decreased cell differentiation. Increased PRSS8 inhibited cancer growth and metastasis in nude mice and inhibited cancer cell migration, invasion, colony and tumor sphere formation.PRSS8 targeted Wnt/beta-catenin, stem-cell, and EMT signaling. | 30115975 |
| 2017-07-08 11:00:00 | Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 and IL-13, down-regulates matriptase as well as prostasin through phosphorylation of the transcriptional regulator | 28490634 |
| 2016-07-02 11:52:00 | a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase. | 26719335 |
| 2016-04-29 14:24:00 | The claudin-4-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1). | 25157135 |
| 2015-02-21 10:17:00 | HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. | 24962579 |
| Type | IDs |
|---|---|
| Synonymous | 2410039E18Rik, AI313909, C79772, CAP1, fr, mCAP1 |
| Gene |
UniProtKB-ID:
Q99L44_MOUSE
UniprotKB:
Q99L44
UniParc:
UPI0000027B93
EMBL:
AY335911,
AC149222,
AF378085,
AF378086,
BC003851,
AB038244
Ensembl:
ENSMUSG00000030800
KO:
mmu:76560
|
| Nucleutide sequences |
EMBL-CDS:
AAL06320.1,
AAQ91197.1,
BAB82496.1,
AAH03851.1,
AAL06319.1
Ensembl_TRS:
ENSMUST00000206124,
ENSMUST00000032988
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000145904,
ENSMUSP00000032988
RefSeq:
XP_006508369.1,
NP_579929.1
|
| Others |
UniRef100:
UniRef100_Q99L44
UniRef90:
UniRef90_Q9ESD1
UniRef50:
UniRef50_Q16651
UniGene:
Mm.5875
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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