| Type | Description |
|---|---|
| Definition | ceroid-lipofuscinosis, neuronal 6 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:55:00 | A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer. | 32597833 |
| 2019-06-01 13:17:00 | Bipolar cell-specific expression of CLN6 slowed significantly the loss of photoreceptor function and photoreceptor cells. This study shows that the deficiency of a gene normally expressed in bipolar cells can cause the loss of photoreceptors and that this can be prevented by bipolar cell-directed treatment. | 29606505 |
| 2014-08-30 12:34:00 | Data indicate that ceroid-lipofuscinosis, neuronal 6 protein Cln6(nclf) mutation leads to deficits in motor coordination, vision, memory, and learning. | 24223841 |
| 2012-07-21 11:05:00 | These findings implicate Cln6 in the survival and maturation of specific neuronal populations during development and make it possible to compare regional Cln6 expression with the distribution of subsequent pathology. | 22012656 |
| 2010-03-01 11:04:00 | Data show a progressive breakdown of axons and synapses in the brains of two different models of NCL: Ppt1(-/-) model of infantile NCL and Cln6(nclf) model of variant late-infantile NCL. | 19640925 |
| Type | IDs |
|---|---|
| Synonymous | 1810065L06Rik, AW743417, D9Bwg1455e, nclf |
| Gene |
UniProtKB-ID:
Q3U466_MOUSE
UniprotKB:
Q3U466
UniParc:
UPI00001C4443
EMBL:
AC164614,
AK154414
Ensembl:
ENSMUSG00000032245
KO:
mmu:76524
|
| Nucleutide sequences |
EMBL-CDS:
BAE32568.1
Ensembl_TRS:
ENSMUST00000034776
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034776
RefSeq:
NP_001028347.1
|
| Others |
UniRef100:
UniRef100_Q3U466
UniRef90:
UniRef90_Q3U466
UniRef50:
UniRef50_Q3U466
UniGene:
Mm.283636
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员