| Type | Description |
|---|---|
| Definition | Rap guanine nucleotide exchange factor (GEF) 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:10:00 | Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. | 31996307 |
| 2018-10-27 10:42:00 | Rapgef2-conditional knockout (cKO) mice and Rapgef6-KO mice exhibited hyperlocomotion phenotype and working-memory defect, both of which could be recognized as schizophrenia-like behavior. | 29747665 |
| 2018-06-02 11:16:00 | This study showed here that the guanine nucleotide exchange factor NCS-Rapgef2 is encoded by a neuron-specific transcript from the Rapgef2 gene locus, and functions as an obligate cAMP sensor for dopamine-dependent ERK activation in hippocampus, amygdala, and ventral striatum | 28948210 |
| 2017-11-04 10:38:00 | Study show that double knockout of Rapgef6 in Rapgef2-cKO mice (Rapgef2/6-dKO) results in marked enlargement of the ectopic cortical mass. While Rapgef2-cKO affects late-born neurons only, Rapgef2/6-dKO affects both early-born and late-born neurons in the developing brain. | 27390776 |
| 2017-10-28 13:15:00 | These results indicate a crucial role of the Rapgef2-Rap1A-ERK-c-jun pathway in regulation of the AJ formation in RGCs. | 28917843 |
| Type | IDs |
|---|---|
| Synonymous | 5830453M24Rik, CNRasGEF, Pdzgef1, RA-GEF-1, mKIAA0313, nRapGEP |
| Gene |
UniProtKB-ID:
E9QNQ4_MOUSE,
Q6NXI4_MOUSE
UniprotKB:
E9QNQ4,
Q6NXI4
UniParc:
UPI00002431E0,
UPI0000F4DDB7
EMBL:
AC124358,
BC067056,
AC164560,
AC157941
Ensembl:
ENSMUSG00000062232
KO:
mmu:76089
|
| Nucleutide sequences |
EMBL-CDS:
AAH67056.1
Ensembl_TRS:
ENSMUST00000118340
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000113778
RefSeq:
XP_006502315.1,
XP_006502313.1,
NP_001093094.2,
XP_030108729.1,
NP_001297465.2,
XP_011238578.1,
XP_011238579.1,
XP_036019282.1
|
| Others |
UniRef100:
UniRef100_Q6NXI4,
UniRef100_E9QNQ4
UniRef90:
UniRef90_F1MSG6,
UniRef90_Q9Y4G8
UniRef50:
UniRef50_Q9Y4G8,
UniRef50_F1MSG6
UniGene:
Mm.31220,
Mm.462396
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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