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76025 Cant1

76025

Cant1

calcium activated nucleotidase 1

protein-coding

Mus musculus

基因描述

Type Description
Definition calcium activated nucleotidase 1

研究结论

Date Results Publications
2020-05-16 10:24:00 To understanding the mechanism of CANT1 mutations in Desbuquois dysplasia type 1, a novel Cant1 knock-in and knock-out murine strains were developed. Both strains present with a skeletal and connective tissue phenotype recapitulating human DBQD1. Cartilage samples and primary chondrocytes demonstrate that CANT1 defects not only affect GAG synthesis, but also GAG elongation, sulfation and PG secretion. 30439444
2018-02-24 11:04:00 CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma. 28330694
2012-08-18 11:02:00 Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation 22451650

名称对应

Type IDs
Synonymous 5830420C20Rik, Apy1h, D11Bwg0554e, Entpd8, SCAN-1, Shapy
Gene
UniProtKB-ID: CANT1_MOUSE
UniprotKB: Q8VCF1
UniParc: UPI000002151D, UPI00001E6B44, UPI0000021518
EMBL: AK006565, AL591404, AK081118, BC020003, AK017942, AK085059, AK049879
Ensembl: ENSMUSG00000025575
KO: mmu:76025
Nucleutide sequences
EMBL-CDS: BAB24655.1, BAC33968.1, AAH20003.1, BAC38139.1, BAC39351.1, BAB31014.1
Ensembl_TRS: ENSMUST00000106289, ENSMUST00000106288, ENSMUST00000164927, ENSMUST00000092378, ENSMUST00000106287, ENSMUST00000017620
Protein sequencees
Ensembl_PRO: ENSMUSP00000101894, ENSMUSP00000126919, ENSMUSP00000101895, ENSMUSP00000101896, ENSMUSP00000090032, ENSMUSP00000017620
RefSeq: NP_001254520.1, XP_006534472.1, XP_006534470.1, NP_083778.2, XP_006534473.1, XP_006534467.1, XP_006534469.1, XP_030102267.1, XP_006534471.1, XP_030102269.1, XP_006534468.1, NP_001020789.1, NP_001254521.1, NP_001020788.1, XP_030102268.1
Others
UniRef100: UniRef100_Q8VCF1
UniRef90: UniRef90_Q8K4Y7
UniRef50: UniRef50_Q8WVQ1
UniGene: Mm.177551
CCDS: CCDS59572.1, CCDS25702.1

全选

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