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7586 ZKSCAN1

7586

ZKSCAN1

zinc finger with KRAB and SCAN domains 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition zinc finger with KRAB and SCAN domains 1

研究结论

Date Results Publications
2020-06-27 10:07:00 The results revealed that ZKSCAN1 circular RNA exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and beta-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restrain the transcriptional activity of Wnt signaling. 31281495
2020-04-04 11:24:00 These results reveal that Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis, which have the important role in the proliferation, migration and invasion ablitities of BCa cells and provide a novel perspective on circRNAs in BCa progression. 31481066
2019-05-18 10:50:00 Dual luciferase activity assay demonstrated that ZNF139 inhibited transcriptional activities of miR-185's promoter in cells transfected with the reporter plasmid encompassing the upstream promoter region of miR-185 along with pcDNA-ZNF139. Our data reveal that ZNF139 might promote MDR gene MDR1/P-gp, MRP-1 and Bcl-2 by prohibiting miR-185 30126848
2018-11-10 11:59:00 High ZNF139 expression is associated with low chemosensitivity in gastric cancer. 29956811
2017-11-04 11:22:00 ZKSCAN1, a zinc finger family gene, is expressed in both linear and circular (circZKSCAN1) forms of RNA in human hepatocellular carcinoma (HCC) tissues and cell lines. 28211215

名称对应

Type IDs
Synonymous KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33
Gene
UniProtKB-ID: ZKSC1_HUMAN, B3KNP9_HUMAN, B3KRF7_HUMAN, E9PC66_HUMAN
UniprotKB: P17029, B3KNP9, B3KRF7, E9PC66
UniParc: UPI000198CEAF, UPI00001A8197, UPI00000726DD, UPI000020F6A8
EMBL: AK091471, CH471091, AK054676, X52349, AK074116, BC022378, AC004522, BC113697, CH236956, AC093619, BX640646, U09848, BC112224
Ensembl: ENSG00000106261
KO: hsa:7586
Nucleutide sequences
EMBL-CDS: EAL23861.1, AAC50264.1, AAH22378.1, EAW76613.1, CAE45792.1, CAA36575.1, BAB84942.1, AAI13698.1, AAI12225.1, BAG51411.1, BAG52369.1
Ensembl_TRS: ENST00000324306, ENST00000535170, ENST00000620510, ENST00000426572
Protein sequencees
Ensembl_PRO: ENSP00000323148, ENSP00000443508, ENSP00000480305, ENSP00000409172
RefSeq: NP_001273983.1, NP_001273984.1, NP_001333510.1, XP_011514861.1, NP_001333508.1, NP_001333509.1, NP_003430.1
Others
UniRef100: UniRef100_B3KNP9, UniRef100_P17029
UniRef90: UniRef90_P17029
UniRef50: UniRef50_P17029
UniGene: Hs.615360
CCDS: CCDS34698.1

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