Nln - neurolysin (metallopeptidase M3 family)-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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75805 Nln

基因描述

Type	Description
Definition	neurolysin (metallopeptidase M3 family)

研究结论

Date	Results	Publications
2020-09-05 13:57:00	Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice.	31486527
2015-11-14 10:52:00	These results confirm the identity of neurolysin as a novel Ang II binding site, suggesting that neurolysin may play a significant role in opposing the pathophysiological actions of the brain RAS and influencing brain morphology.	25147932
2014-10-11 10:18:00	These results suggest the exciting new possibility that Nln is a key enzyme for energy metabolism and could be a novel therapeutic target to improve glucose uptake and insulin sensitivity.	24719317
2014-05-17 11:21:00	Neurolysin plays a role in modulating the brain's response to stroke and recovery after stroke.	24164478
2012-05-12 11:50:00	novel angiotensin binding site	22039052

名称对应

Type	IDs
Synonymous	4930472G13Rik, C79345
Gene	UniProtKB-ID: NEUL_MOUSE UniprotKB: Q91YP2 UniParc: UPI00000E88E2 EMBL: AK146364, BC025520, AK079090, BC016224 Ensembl: ENSMUSG00000021710 KO: mmu:75805
Nucleutide sequences	EMBL-CDS: AAH25520.1, AAH16224.1, BAE27114.1, BAC37533.1 Ensembl_TRS: ENSMUST00000109315
Protein sequencees	Ensembl_PRO: ENSMUSP00000104938 RefSeq: NP_083723.1, XP_011243003.1, XP_036014107.1, XP_011243002.1, XP_036014106.1, XP_011243001.1, XP_030103312.1
Others	UniRef100: UniRef100_Q91YP2 UniRef90: UniRef90_Q02038 UniRef50: UniRef50_Q02038 UniGene: Mm.127692 CCDS: CCDS36772.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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全选

Pubmed编号	文献信息	发表日期	相关基因
31486527	Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice. J Neurochem Srinidhi Jayaraman , Abdullah Al Shoyaib , Joanna Kocot , Heidi Villalba , Faisal F Alamri , Mamoon Rashid , Naomi J Wangler , Ekram A Chowdhury , Nadezhda German , Thiruma V Arumugam , Thomas J Abbruscato , Vardan T Karamyan	2020-04-01	-
24719317	Neurolysin knockout mice generation and initial phenotype characterization. J Biol Chem Diogo M L P Cavalcanti , Leandro M Castro , JosÃ© C Rosa Neto , Marilia Seelaender , Rodrigo X Neves , Vitor Oliveira , FÃ¡bio L Forti , Leo K Iwai , Fabio C Gozzo , Mihail Todiras , Ines Schadock , Carlos C Barros , Michael Bader , Emer S Ferro	2014-05-30	-
24719333	Hepatic scavenger receptor BI protects against polymicrobial-induced sepsis through promoting LPS clearance in mice. J Biol Chem Ling Guo , Zhong Zheng , Junting Ai , Bin Huang , Xiang-An Li	2014-05-23	-
24164478	Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. J. Neurochem. Mamoon Rashid , Naomi J Wangler , Li Yang , Kaushik Shah , Thiruma V Arumugam , Thomas J Abbruscato , Vardan T Karamyan	2014-04-01	Nln
25147932	Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PLoS One Robert C Speth , Eduardo J Carrera , Catalina BretÃ³n , Andrea Linares , Luz Gonzalez-Reiley , Jamala D Swindle , Kira L Santos , Ines Schadock , Michael Bader , Vardan T Karamyan	2014-01-01	-
23604909	Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm. Genome Mai Nakahara , Hiroki Tateyama , Masatake Araki , Naomi Nakagata , Ken-ichi Yamamura , Kimi Araki	2013-06-01	Rex2, Cnot6, Foxp1, Mta1, Pop5, Bmpr1a, Dnajc5, Ctbp2, Celf1, Mark2, Sfxn1, Gli2, Klf12, Kpna2, Alad, Nedd4, Pkig, Plcb4, Pvt1, Rbmxl1, Rbpms, Rbpj, Ralbp1, Rnf2, Stmn2, Camkk2, Etl4, Hmgcs1, Daam1, Tnrc6b, Tead1, Tmem11, Itpk1, Arl15, Hmbox1, Traf3, Tsix, Slc25a51, Tnrc6a, Tmem161a, Usp32, Abcc4, Pacsin2, Zfp407, G3bp1, Txnl4a, Sox2ot, Mreg, Snhg3, Zdhhc18, Txnrd1, Carhsp1, Rev1, Vapb, Chst12, Rpl23, Cyb5b, Psmd12, Rnmt, Setd8, Rps13, 1110002J07Rik, 2410006H16Rik, Qrich1, Wdfy1, Ten1, Mier2, Mutyh, Ist1, Fryl, Rab10os, Fblim1, Tti1, Nln, Msi2, Csrnp3, Sh3bp4
22039052	Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site. J Biol Chem Naomi J Wangler , Kira L Santos , Ines Schadock , Fred K Hagen , Emanuel Escher , Michael Bader , Robert C Speth , Vardan T Karamyan	2012-01-02	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
18799693	Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. Gwenn M Hansen , Diane C Markesich , Michael B Burnett , Qichao Zhu , Karen M Dionne , Lizabeth J Richter , Richard H Finnell , Arthur T Sands , Brian P Zambrowicz , Alejandro Abuin	2008-10-01	Gm11335, Gm17762, A930017K11Rik, BC028777, Gm13999, Gm11696, Gm12359, Gm10589, D030047H15Rik, Gm10856, Gm10685, Gm10062, Gm10433, Gm10648, Gm10840, Gm15441, Gm10684, Gm9900, Gm10822, Gm10687, Gm11744, Gm10747, Arih2os, B230344G16Rik, Fmr1os, Tmem51os1, Gm14488, Gm13033, Gm10789, Gm10615, Gm1976, Gm9967, Gm9917, Gm1974, Gm11496, Gm13580, Gm2085, Gm2183, Gm2245, Tbx3os1, Gm12980, Gm2329, Lncenc1, Gm2381, Snhg12, Gm2479, Gm12942, Gm2529, Gm2533, Rpl30-ps7, Rsf1os2, Gm2695, 2810416G20Rik, Rpl30-ps6, Gm2773, Gm2788, Dynlt1f, Gm9793, Gm2885, Gm2920, Gm15506, Gm11627, Gm10518, Gm13496, Gm3134, Gm12827, Gm3143, Gm10144, Ahnak2, Gm3196, Gm13242, Gm3325, Gm13247, Gm10863, Gm13157, 4930522L14Rik, Gm3552, Gm15226, Gm3604, Gm3643, BC005561, Gm3716, 2810410L24Rik, Gm10282, Gm3839, Nhsl2, 4732419C18Rik, Gm3906, Gm3973, Gm4013, Apol7d, Gm12057, Gm10489, Rex2, 1110002L01Rik, Gm4189, Gm4204, 4632428C04Rik, 9130023H24Rik
18614015	A mitochondrial protein compendium elucidates complex I disease biology. Cell David J Pagliarini , Sarah E Calvo , Betty Chang , Sunil A Sheth , Scott B Vafai , Shao-En Ong , Geoffrey A Walford , Canny Sugiana , Avihu Boneh , William K Chen , David E Hill , Marc Vidal , James G Evans , David R Thorburn , Steven A Carr , Vamsi K Mootha	2008-07-11	Acacb, Hscb, Gadd45gip1, Lars2, Acad11, Chchd10, Nt5dc3, Slc25a41, Nt5m, Cyp27a1, Acly, Ndufb11, Gldc, Rexo2, Rars, Aldh6a1, Slc25a47, Rdh14, Ppif, Ldhal6b, Me2, Glyat, Slc25a45, Acaca, Nt5c3, Mrpl10, Mrpl41, Mrpl30, Aldh1l1, Mthfs, Shmt2, Atic, Mthfd1, Mat2b, Fam210a, Gpt2, Lyrm2, Rdh13, Mtrf1l, Atad3a, Rars2, Sccpdh, Me3, Maob, Dut, Cyp11b1, Fdps, Akr7a5, Msra, Krt5, Cox6b1, Qdpr, Acat1, Acat2, Aldh7a1, Pcca, Etfb, Etfa, Nudt19, Acadl, Acadm, Acadvl, Acaa1a, Acads, Aco1, Aco2, Prosc, Afg3l1, Adsl, Agxt, Ak2, Ak4, Akap1, Alas1, Alas2, Abcd1, Aldh2, Aldh3a2, Gfer, Acsm1, Slc25a4, Slc25a5, Prdx3, Prdx6, Mrps2, Arg2, Rhoa, Atp5a1, Atp5b, Atp5c1, Atp5f1, Atp5g1, Atp5j, Atp5k, Atpif1, Auh, Akr1b7, Bad, Bak1

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