| Type | Description |
|---|---|
| Definition | sestrin 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:50:00 | Sestrin3 enhances macrophage-mediated generation of T helper 1 and T helper 17 cells in a mouse colitis model. | 32154559 |
| 2020-05-16 11:08:00 | Sestrin 3 (Sesn3) belongs to a small protein family that has been implicated in multiple biological processes including anti-oxidative stress, anti-aging, cell signaling, and metabolic homeostasis. Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway. | 31351129 |
| 2020-04-11 10:11:00 | Sestrins are critical mediators of exercise benefits. Genetic ablation of Sestrins prevents mice from acquiring metabolic benefits of exercise and improving their endurance through training. Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it is a major effector of exercise metabolism. AKT and PGC1alpha are critical for the Sestrin effects in extending endurance. | 31929512 |
| 2019-05-25 12:18:00 | SESN3 plays a key role in exercise training-mediated glucose metabolism in skeletal muscle. | 30048751 |
| 2015-05-23 11:49:00 | Sesn3 liver-specific knockout mice exhibit insulin resistance and glucose intolerance. Sesn3 interacts with and activates mTORC2 and subsequently stimulates Akt phosphorylation at Ser473. | 25377878 |
| Type | IDs |
|---|---|
| Synonymous | 5630400E15Rik, BC003348, SEST3 |
| Gene |
UniProtKB-ID:
SESN3_MOUSE,
A2RSF4_MOUSE
UniprotKB:
Q9CYP7,
A2RSF4
UniParc:
UPI000002395C
EMBL:
AK155398,
BC132086,
AK017464,
BC138690
Ensembl:
ENSMUSG00000032009
KO:
mmu:75747
|
| Nucleutide sequences |
EMBL-CDS:
BAE33242.1,
BAB30755.1,
AAI38691.1,
AAI32087.1
Ensembl_TRS:
ENSMUST00000208222
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000146362
RefSeq:
NP_084537.2
|
| Others |
UniRef100:
UniRef100_Q9CYP7
UniRef90:
UniRef90_Q9CYP7
UniRef50:
UniRef50_P58005
UniGene:
Mm.325126,
Mm.439776
CCDS:
CCDS22820.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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