| Type | Description |
|---|---|
| Definition | lysine (K)-specific demethylase 5B |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis. | 32868382 |
| 2020-03-14 10:25:00 | In this study, we demonstrate that CD34(+) and CD34(-) subpopulations carrying the BRAF(V600E) mutation confer differential sensitivity to targeted BRAF inhibition. Through elevated KDM5B expression, melanoma cells shift toward a more drug-tolerant, CD34(-) state upon exposure to BRAF inhibitor or combined BRAF inhibitor and MEK inhibitor treatment | 30523048 |
| 2020-01-25 11:16:00 | A novel role of KDM5B in metabolism, as KDM5B-KO mice display growth retardation and improved insulin sensitivity. | 31467927 |
| 2019-05-11 10:54:00 | KDM5B regulates nucleosome positioning in embryonic stem cells. | 30940185 |
| 2019-02-02 10:38:00 | JARID1B bound to NFkB promoter and affected NFkB expression, resulting in the up-regulation of VEGF-A, promoting proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension. | 30172777 |
| Type | IDs |
|---|---|
| Synonymous | 2010009J12Rik, 2210016I17Rik, AW556288, D1Ertd202e, Jarid1b, PLU-1, PUT1, Plu1, RBBP2H1A, Rb-Bp2, mKIAA4034 |
| Gene |
UniProtKB-ID:
KDM5B_MOUSE
UniprotKB:
Q80Y84
UniParc:
UPI0000355E3E,
UPI000005FB6E
EMBL:
AY082429,
AY082430,
AK220451,
BC057318,
AK041304,
BC048180
Ensembl:
ENSMUSG00000042207
KO:
mmu:75605
|
| Nucleutide sequences |
EMBL-CDS:
AAH57318.1,
BAC30898.1,
BAD90482.1,
AAL92849.1,
AAL92848.1,
AAH48180.1
Ensembl_TRS:
ENSMUST00000047714,
ENSMUST00000112198
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000107817,
ENSMUSP00000038138
RefSeq:
NP_690855.2,
XP_011246392.1,
XP_017168106.1,
XP_017168105.1
|
| Others |
UniRef100:
UniRef100_Q80Y84
UniRef90:
UniRef90_Q80Y84
UniRef50:
UniRef50_Q80Y84
UniGene:
Mm.28995,
Mm.391994
CCDS:
CCDS35716.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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