| Type | Description |
|---|---|
| Definition | synaptic vesicle glycoprotein 2c |
| Date | Results | Publications |
|---|---|---|
| 2018-11-10 10:57:00 | Study showed that SV2C is highly expressed in the basal ganglia and hippocampus of mice and that there is a specific and progressive decrease in SV2C mRNA and protein expression in both Huntington's disease (HD) mice and a cell model. These findings suggest that the synaptic dysfunction in HD results from the mutant Htt-mediated inhibition of SV2C transcriptional expression. | 29713895 |
| 2014-09-20 11:47:00 | Results showed that SV2C, a poorly functionally characterized protein is strongly involved in normal operation of the basal ganglia network and could be also involved in system adaptation in basal ganglia pathological conditions. | 23458503 |
| 2011-04-16 13:42:00 | SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area. | 20869353 |
| 2010-01-21 00:00:00 | findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A | 16543415 |
| 2010-01-21 00:00:00 | Botulinum neurotoxin A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B. | 16545378 |
| Type | IDs |
|---|---|
| Synonymous | 4930527L09Rik, AI841971 |
| Gene |
UniProtKB-ID:
SV2C_MOUSE
UniprotKB:
Q69ZS6
UniParc:
UPI00001E3167
EMBL:
AK173092
Ensembl:
ENSMUSG00000051111
KO:
mmu:75209
|
| Nucleutide sequences |
EMBL-CDS:
BAD32370.1
Ensembl_TRS:
ENSMUST00000161263
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124473
RefSeq:
XP_036014095.1,
NP_083486.1,
XP_030103300.1
|
| Others |
UniRef100:
UniRef100_Q69ZS6
UniRef90:
UniRef90_Q496J9
UniRef50:
UniRef50_Q496J9
UniGene:
Mm.40436
CCDS:
CCDS49333.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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