| Type | Description |
|---|---|
| Definition | Werner syndrome RecQ like helicase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:44:00 | MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment. | 32652764 |
| 2020-12-19 13:44:00 | Repeat expansions confer WRN dependence in microsatellite-unstable cancers. | 32999459 |
| 2020-02-15 10:17:00 | Both K1127 and K1117 is essential for the recruitment of this protein at DNA damage site and for successful DNA repair. | 31085421 |
| 2019-12-21 10:54:00 | WRN was selectively essential in microsatellite instability models in vitro and in vivo, yet dispensable in models of cancers that are microsatellite stable; WRN depletion induced double-stranded DNA breaks and promoted apoptosis and cell cycle arrest selectively in MSI models; MSI cancer models required the helicase activity of WRN, but not its exonuclease activity | 30971823 |
| 2019-10-12 11:02:00 | HERC2 is a master regulator of G-quadruplex, a DNA secondary structure that triggers genomic instability, through BLM, WRN, and RPA, and may serve as a potential molecular target in cancer therapy | 30279242 |
| Type | IDs |
|---|---|
| Synonymous | RECQ3, RECQL2, RECQL3 |
| Gene |
UniProtKB-ID:
WRN_HUMAN
UniprotKB:
Q14191
UniParc:
UPI000013E49D
EMBL:
AC084736,
AY442327,
AF181897,
AY818673,
L76937,
AF181896,
AF091214
Ensembl:
ENSG00000165392
KO:
hsa:7486
|
| Nucleutide sequences |
EMBL-CDS:
AAR05448.1,
AAX21098.1,
AAC41981.1,
AAC63361.1,
AAF06162.1
Ensembl_TRS:
ENST00000298139
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000298139
RefSeq:
XP_011542942.1,
NP_000544.2,
XP_011542941.1,
XP_024303033.1
|
| Others |
UniRef100:
UniRef100_Q14191
UniRef90:
UniRef90_Q14191
UniRef50:
UniRef50_Q14191
UniGene:
Hs.632050
CCDS:
CCDS6082.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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