| Type | Description |
|---|---|
| Definition | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:29:00 | Inactivation of endothelial cell phosphoinositide 3-kinase beta inhibits tumor angiogenesis and tumor growth. | 32879446 |
| 2020-07-11 12:37:00 | macropinocytosis in response to receptor tyrosine kinase activation is strikingly dependent on a single class I PI3K isoform, namely PI3Kbeta (containing the p110beta catalytic subunit encoded by PIK3CB). Loss of PI3Kbeta expression or activity blocks macropinocytosis at early steps. | 31409694 |
| 2020-06-20 11:12:00 | While the loss of endothelial PI3Kbeta activity produces cardioprotective effects, cardiac myocyte PI3Kbeta is protective against myocardial ischaemic injury. | 30496354 |
| 2018-12-01 11:38:00 | The crucial role of p110beta and the more subtle role of p110alpha in the production of PIP3 molecular species following platelet stimulation has been demonstrated. | 29902570 |
| 2017-12-23 10:33:00 | these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis. | 26896753 |
| Type | IDs |
|---|---|
| Synonymous | 1110001J02Rik, AI447572, p110beta |
| Gene |
UniProtKB-ID:
PK3CB_MOUSE
UniprotKB:
Q8BTI9
UniParc:
UPI00001C4531
EMBL:
AK090116,
AK154106,
CH466560
Ensembl:
ENSMUSG00000032462
KO:
mmu:74769
|
| Nucleutide sequences |
EMBL-CDS:
BAC41102.1,
EDL20998.1,
BAE32380.1
Ensembl_TRS:
ENSMUST00000035037
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000035037
RefSeq:
XP_030100548.1,
XP_011241131.1,
XP_011241132.1,
NP_083370.2
|
| Others |
UniRef100:
UniRef100_Q8BTI9
UniRef90:
UniRef90_P42338
UniRef50:
UniRef50_P42338
UniGene:
Mm.213128
CCDS:
CCDS23432.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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