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7469 NELFA

7469

NELFA

negative elongation factor complex member A

protein-coding

Homo sapiens

基因描述

Type Description
Definition negative elongation factor complex member A

研究结论

Date Results Publications
2021-03-20 13:35:00 Stress-induced nuclear condensation of NELF drives transcriptional downregulation. 33548202
2021-02-06 13:49:00 The noncoding function of NELFA mRNA promotes the development of oesophageal squamous cell carcinoma by regulating the Rad17-RFC2-5 complex. 31845510
2017-11-25 15:03:00 A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. 27282391
2014-02-08 10:47:00 These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A and NELF-B, relative to other factors in the overall gene induction sequence. 24097989
2012-11-17 11:04:00 data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei 19245807

名称对应

Type IDs
Synonymous NELF-A, P/OKcl.15, WHSC2
Gene
UniProtKB-ID: NELFA_HUMAN, A0A0C4DFX9_HUMAN
UniprotKB: Q9H3P2, A0A0C4DFX9
UniParc: UPI00004A2565, UPI0000038D6D, UPI000016994B
EMBL: AB044549, CH471131, AK126056, BC002764, AL132868, AF131751, AF101434
Ensembl: ENSG00000185049
KO: hsa:7469
Nucleutide sequences
EMBL-CDS: EAW82546.1, AAD20034.1, AAC72982.1, BAG54283.1, BAB18651.1, AAH02764.2
Gene_ORFName: P/OKcl.15
Ensembl_TRS: ENST00000382882, ENST00000542778
Protein sequencees
Ensembl_PRO: ENSP00000372335, ENSP00000445757
RefSeq: XP_016864078.1, NP_005654.4
Others
UniRef100: UniRef100_Q9H3P2
UniRef90: UniRef90_Q9H3P2
UniRef50: UniRef50_Q9H3P2
UniGene: Hs.21771
CCDS: CCDS3358.2

全选

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研究热度

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