| Type | Description |
|---|---|
| Definition | ATP-binding cassette, sub-family A (ABC1), member 12 |
| Date | Results | Publications |
|---|---|---|
| 2017-07-29 12:53:00 | these findings suggest an essential role for ABCA12 in transferring not only lipids, which are required for the formation of multilamellar structures in the stratum corneum, but also proteolytic enzymes that are required for normal desquamation. | 27551807 |
| 2014-11-08 13:42:00 | Data indicate that ABC transporter A family member 12 knockout (Abca12(-/-)) epidermis had 5-fold more beta-glucocerebrosidase (GCase) protein, and a 5-fold increase in GCase activity. | 24293640 |
| 2014-04-19 11:52:00 | ABCA12 mutations result in defective lipid transport via lamellar granules in the keratinocytes, leading to ichthyosis phenotypes from malformation of the stratum corneum lipid barrier. | 23954554 |
| 2014-04-05 11:49:00 | ABCA12 regulates the cellular cholesterol metabolism via an LXRbeta-dependent posttranscriptional mechanism. | 23931754 |
| 2010-12-11 10:54:00 | Results indicate that disrupted keratinocyte differentiation during the fetal development is involved in the pathomechanism of HI and, during maturation, Abca12(-/-) epidermal keratinocytes regain normal differentiation processes. | 20489143 |
| Type | IDs |
|---|---|
| Synonymous | 4832428G11Rik, 4833417A11Rik |
| Gene |
UniProtKB-ID:
E9Q876_MOUSE
UniprotKB:
E9Q876
UniParc:
UPI00019867AC
EMBL:
AC138589,
AC107789
Ensembl:
ENSMUSG00000050296
KO:
mmu:74591
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000087268
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000084523
RefSeq:
NP_780419.2
|
| Others |
UniRef100:
UniRef100_E9Q876
UniRef90:
UniRef90_B2RY21
UniRef50:
UniRef50_Q86UK0
UniGene:
Mm.159251
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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