| Type | Description |
|---|---|
| Definition | WASP actin nucleation promoting factor |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:00:00 | WASP functions in immune defense and homeostasis through the regulation of actin cytoskeleton-dependent cellular processes as well as processes uncoupled with actin polymerization like nuclear transcription programs. (Review) | 31047647 |
| 2019-09-28 11:23:00 | We provide molecular evidence that the hyperactivity of X-linked neutropenia neutrophils is caused by WASp in a constitutively open conformation due to contingent phosphorylation of the critical tyrosine-293 and plasma membrane localization. | 30124469 |
| 2019-07-06 10:12:00 | This study shows that WASp plays a critical role in thymic output, which highly correlates with the subcellular location and level of F-actin in T cells. | 28931895 |
| 2019-05-11 10:18:00 | the expression of WASP and WIP is frequently low or absent in anaplastic large cell lymphoma (ALCL) compared to other T cell lymphomas. | 30510251 |
| 2019-04-27 10:29:00 | This is the first study to associate somatically acquired WASP mutations with juvenile myelomonocytic leukemia (JMML)and increases insight in the complexity of the genomic landscape of JMML that shows low recurrent mutations concomitant with general hyperactivation of RAS pathway signaling. | 29316027 |
| Type | IDs |
|---|---|
| Synonymous | IMD2, SCNX, THC, THC1, WASP, WASPA |
| Gene |
UniProtKB-ID:
WASP_HUMAN,
A0A024QYX8_HUMAN
UniprotKB:
P42768,
A0A024QYX8
UniParc:
UPI000003CA0A
EMBL:
U19927,
U18935,
U12707,
CH471224,
BC002961,
AF115549,
BC012738,
AF196970
Ensembl:
ENSG00000015285
KO:
hsa:7454
|
| Nucleutide sequences |
EMBL-CDS:
AAC50140.1,
AAA60381.1,
AAH02961.1,
AAA62663.1,
AAD26691.1,
AAH12738.1,
EAW50759.1,
EAW50758.1
Gene_ORFName:
hCG_19822
Ensembl_TRS:
ENST00000376701
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365891
RefSeq:
XP_016885275.1,
XP_011542279.1,
NP_000368.1
|
| Others |
UniRef100:
UniRef100_P42768
UniRef90:
UniRef90_P42768
UniRef50:
UniRef50_P42768
UniGene:
Hs.2157
CCDS:
CCDS14303.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员