| Type | Description |
|---|---|
| Definition | sclerostin |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:15:00 | Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFbeta inducible early gene-1 knockout female mice. | 31975377 |
| 2020-12-19 13:43:00 | Sclerostin expression in trabecular bone is downregulated by osteoclasts. | 32792620 |
| 2020-11-21 13:18:00 | Sclerostin inhibits interleukin-1beta-induced late stage chondrogenic differentiation through downregulation of Wnt/beta-catenin signaling pathway. | 32976505 |
| 2020-08-01 13:00:00 | Mechanically stretched osteocytic IDG-SW3 cells exhibit decreased Sost expression. Mechanical stretch induces Sost suppression via Piezo1-Akt pathway in osteocytes. | 31708103 |
| 2020-07-25 12:03:00 | Study in knockout mice provides evidence that bone 1alpha-hydroxylase Cyp27b1 may play a central role in the regulation of sclerostin, BMP2, and FGF23 in chronic kidney disease. Increased osteocytic 1,25(OH)2D production, triggered by renal malfunction, may represent a "primary defensive response" to protect the organism from ectopic calcification by increasing sclerostin and suppressing BMP2 production. | 31292298 |
| Type | IDs |
|---|---|
| Synonymous | 5430411E23Rik |
| Gene |
UniProtKB-ID:
SOST_MOUSE
UniprotKB:
Q99P68
UniParc:
UPI0000020B7E
EMBL:
AF326740,
AL591145,
BC137833,
FQ790373,
CH466558,
BC137832,
AK017295,
AF326737
Ensembl:
ENSMUSG00000001494
KO:
mmu:74499
|
| Nucleutide sequences |
EMBL-CDS:
EDL34073.1,
AAI37834.1,
AAK13455.1,
AAK13452.1,
AAI37833.1,
BAB30678.1
Ensembl_TRS:
ENSMUST00000001534
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000001534
RefSeq:
NP_077769.4,
XP_006534439.1
|
| Others |
UniRef100:
UniRef100_Q99P68
UniRef90:
UniRef90_Q99P68
UniRef50:
UniRef50_Q9BQB4
UniGene:
Mm.265602
CCDS:
CCDS25481.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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