| Type | Description |
|---|---|
| Definition | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:51:00 | Developmentally Programmed Tankyrase Activity Upregulates beta-Catenin and Licenses Progression of Embryonic Genome Activation. | 32442396 |
| 2019-01-19 11:39:00 | Study using Villin-creERT2;Tnks1-/-;Tnks2fl/fl mice, which harbored conventional Tnks1 deletion and inducible intestinal epithelium-specific Tnks2 knockout, shows that tankyrases regulate adult intestinal Lgr5+ stem cells and epithelium homeostasis by preventing cell death and promoting cell proliferation. | 30260955 |
| 2017-10-28 13:40:00 | Tank1/Tank2 inhibition aggravates kidney injury in the absence of CD2AP. | 27441654 |
| 2017-08-05 11:58:00 | a new function of RNF146 and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT proteins at the apical membrane, is reported. | 27521426 |
| 2017-07-15 11:03:00 | These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation. | 27328430 |
| Type | IDs |
|---|---|
| Synonymous | 5430432P15Rik, AA517131, AI662480, ARTD6, TNKS-2, Tank2 |
| Gene |
UniProtKB-ID:
TNKS2_MOUSE
UniprotKB:
Q3UES3
UniParc:
UPI00001C62C4
EMBL:
BC063101,
AK149368,
AC116128,
AK047094
Ensembl:
ENSMUSG00000024811
KO:
mmu:74493
|
| Nucleutide sequences |
EMBL-CDS:
AAH63101.1,
BAE28838.1,
BAC32960.2
Ensembl_TRS:
ENSMUST00000025729
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025729
RefSeq:
XP_011245684.1,
NP_001157107.1,
XP_006527472.1,
XP_006527471.1
|
| Others |
UniRef100:
UniRef100_Q3UES3
UniRef90:
UniRef90_Q9H2K2
UniRef50:
UniRef50_O95271
UniGene:
Mm.249310
CCDS:
CCDS50426.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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