| Type | Description |
|---|---|
| Definition | ring finger protein 145 |
| Date | Results | Publications |
|---|---|---|
| 2019-03-30 10:59:00 | n the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation | 30543180 |
| 2018-06-09 10:41:00 | Mechanistic studies show that RNF145 triggers ubiquitination of SCAP on lysine residues within a cytoplasmic loop essential for COPII binding, potentially inhibiting its transport to Golgi and subsequent processing of SREBP-2. | 29068315 |
| 2017-08-19 10:20:00 | we report the identification of RNF145 as an ER-resident E3 ubiquitin ligase that is transcriptionally controlled by LXR. | 28231341 |
| 2016-05-14 10:58:00 | implicated in proteostasis of Nox2 complex | 26194095 |
| Type | IDs |
|---|---|
| Synonymous | 3732413I11Rik, TMRF1 |
| Gene |
UniProtKB-ID:
RN145_MOUSE,
Q3UTM8_MOUSE,
Q8BU61_MOUSE
UniprotKB:
Q5SWK7,
Q3UTM8,
Q8BU61
UniParc:
UPI0000021698,
UPI00005ABED3,
UPI00000EAA9F
EMBL:
AK087359,
AK139310,
AK043002,
BC040799,
AK014408,
AL603913
Ensembl:
ENSMUSG00000019189
KO:
mmu:74315
|
| Nucleutide sequences |
EMBL-CDS:
BAB29332.1,
BAC31431.1,
AAH40799.1,
BAE23952.1,
BAC39852.1
Ensembl_TRS:
ENSMUST00000019333,
ENSMUST00000101327
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019333,
ENSMUSP00000098881
RefSeq:
XP_030102252.1,
XP_006534420.1,
NP_083138.2,
XP_006534421.1,
NP_001350095.1,
NP_001160025.1
|
| Others |
UniRef100:
UniRef100_Q8BU61,
UniRef100_Q5SWK7
UniRef90:
UniRef90_Q8BU61,
UniRef90_Q5SWK7
UniRef50:
UniRef50_Q8BU61,
UniRef50_Q5SWK7
UniGene:
Mm.156771
CCDS:
CCDS24565.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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