| Type | Description |
|---|---|
| Definition | katanin p80 (WD40-containing) subunit B 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:52:00 | Study uncovered an unexpected role of the p60-MIT and p80-CTD domains of katanin in the oligomerization and regulation of the protein. p80-CTD mediates the assembly of p60-MIT:p80-CTD heterodimers into heterotetramers that have an impact on katanin MT end and lattice binding as well as on the severing activity of the enzyme. The heterotetrameric structure of the p60-MIT:p80-CTD K555A/R591A mutant revealed a domain swap. | 31353241 |
| 2019-07-20 11:52:00 | This study structurally and functionally characterized the interaction between the two katanin subunits that is mediated by the p60-MIT domain and the p80 C-terminal domain (p80-CTD). p60-MIT and p80-CTD form a tight heterodimeric complex, whose high-resolution structure was determined by X-ray crystallography. | 29097679 |
| 2018-07-14 11:27:00 | Katnb1 is ubiquitously expressed during embryonic development, although a stronger expression is seen in the crown cells of the gastrulation organizer, the murine node. Furthermore, null and hypomorphic Katnb1 gene mutations show a novel correlation between Katnb1 dysregulation and the development of impaired left-right signaling, including cardiac malformations. | 28791777 |
| 2012-09-29 11:08:00 | Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development | 22654669 |
| 2010-01-21 00:00:00 | Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5 is required for efficient p60/katanin removal | 19261606 |
| Type | IDs |
|---|---|
| Synonymous | 2410003J24Rik, KAT |
| Gene |
UniProtKB-ID:
KTNB1_MOUSE
UniprotKB:
Q8BG40
UniParc:
UPI000000B75C
EMBL:
AK049345,
BC024500,
BC045200,
AK010364,
AK031630,
AK034103,
AK087973
Ensembl:
ENSMUSG00000031787
KO:
mmu:74187
|
| Nucleutide sequences |
EMBL-CDS:
BAC27487.1,
BAC33697.1,
BAC28588.1,
AAH45200.1,
BAB26884.1,
AAH24500.1,
BAC40067.1
Ensembl_TRS:
ENSMUST00000034239
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034239
RefSeq:
NP_083081.2,
XP_006531475.1,
XP_006531474.1,
XP_006531473.1
|
| Others |
UniRef100:
UniRef100_Q8BG40
UniRef90:
UniRef90_Q9BVA0
UniRef50:
UniRef50_Q9BVA0
UniGene:
Mm.28382
CCDS:
CCDS22555.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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