| Type | Description |
|---|---|
| Definition | lon peptidase 1, mitochondrial |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:44:00 | LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation. | 32936696 |
| 2020-06-20 12:13:00 | upregulation of LonP1 mitigates cardiac injury by preventing oxidative damage of proteins and lipids, preserving mitochondrial redox balance and reprogramming bioenergetics by reducing Complex I content and activity. Mechanisms that promote the upregulation of LonP1 could be beneficial in protecting the myocardium from cardiac stress and limiting I/R injury | 30625302 |
| 2020-02-08 12:15:00 | LonP1(+/-) mouse embryonal fibroblasts also showed Eral1 accumulation, but no systematic effect on mitoribosomal subunits. | 31547314 |
| 2018-04-28 10:50:00 | these findings suggest that Lon protease may be particularly vulnerable to inactivation in conditions associated with elevated oxidative stress resulting in mitochondrial dysfunction and neuron cell death, an early event in the pathogenesis of Parkinson's disease | 28365360 |
| 2017-10-28 13:15:00 | Lon preferentially degrades the phosphorylated subunits of CcO and plays a role in the regulation of CcO activity in hypoxia and ischemia/reperfusion injury. | 28442264 |
| Type | IDs |
|---|---|
| Synonymous | 1200017E13Rik, LON, Prss15 |
| Gene |
UniProtKB-ID:
LONM_MOUSE
UniprotKB:
Q8CGK3
UniParc:
UPI0000026710
EMBL:
AK159302,
AK004820,
AK161983,
AK160071,
AY190302,
AK157474
Ensembl:
ENSMUSG00000041168
KO:
mmu:74142
|
| Nucleutide sequences |
EMBL-CDS:
BAE35606.1,
AAN85210.1,
BAE34094.1,
BAB23591.1,
BAE34972.1,
BAE36666.1
Ensembl_TRS:
ENSMUST00000047226
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041814
RefSeq:
NP_083058.2
|
| Others |
UniRef100:
UniRef100_Q8CGK3
UniRef90:
UniRef90_Q924S5
UniRef50:
UniRef50_Q924S5
UniGene:
Mm.329136
CCDS:
CCDS28910.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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