| Type | Description |
|---|---|
| Definition | synovial apoptosis inhibitor 1, synoviolin |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:53:00 | Sel1L-Hrd1 ER-associated degradation maintains beta cell identity via TGF-beta signaling. | 32182217 |
| 2020-07-04 10:53:00 | Deficiency in macrophages protects mice against lipopolysaccharide-induced septic shock, and knockdown of Usp15 in Hrd1-knockout macrophages restores the reduced IL-6 production. | 31477895 |
| 2020-06-06 10:27:00 | The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. | 30843874 |
| 2019-10-05 10:58:00 | HRD1-ERAD catalyzes polyubiquitin conjugation onto CREBH at lysine 294 for its proteasomal degradation, bridging a multi-organ crosstalk in regulating growth, circadian behavior, and female fertility through regulating the CREBH-FGF21 regulatory axis. | 30389664 |
| 2019-03-30 10:59:00 | n the absence of both RNF145 and gp78, Hrd1, a third UBE2G2-dependent E3 ligase, partially regulates HMGCR activity. Our findings reveal a critical role for the sterol-responsive RNF145 in HMGCR regulation and elucidate the complexity of sterol-accelerated HMGCR degradation | 30543180 |
| Type | IDs |
|---|---|
| Synonymous | 1200010C09Rik, AW211966, C85322, D530017H19Rik, Hrd1 |
| Gene |
UniProtKB-ID:
SYVN1_MOUSE,
A0A0R4J1R1_MOUSE
UniprotKB:
Q9DBY1,
A0A0R4J1R1
UniParc:
UPI0000022449,
UPI0000F3BE68,
UPI00000E8EE9
EMBL:
BC080722,
BC057917,
AK122558,
AC131692,
BC042199,
AK004688,
BC046829
Ensembl:
ENSMUSG00000024807
KO:
mmu:74126
|
| Nucleutide sequences |
EMBL-CDS:
AAH46829.1,
AAH42199.1,
AAH80722.1,
BAC65840.3,
BAB23474.2,
AAH57917.1
Ensembl_TRS:
ENSMUST00000138532,
ENSMUST00000134667
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000114960,
ENSMUSP00000114843
RefSeq:
NP_001158181.1,
XP_006531913.1,
NP_083045.4
|
| Others |
UniRef100:
UniRef100_Q9DBY1,
UniRef100_A0A0R4J1R1
UniRef90:
UniRef90_Q9DBY1
UniRef50:
UniRef50_Q86TM6
UniGene:
Mm.149870
CCDS:
CCDS29487.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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