| Type | Description |
|---|---|
| Definition | poly(A)-specific ribonuclease (deadenylation nuclease) |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:37:00 | Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. | 31273937 |
| 2013-01-05 10:53:00 | these data indicate that PARN modulates decay of a defined set of mRNAs in mammalian cells and implicate this deadenylase in coordinating control of genes required for cell movement. | 22956911 |
| 2012-10-13 10:03:00 | poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus | 22727665 |
| 2010-01-21 00:00:00 | A modeled PARN, which shows that the RRM domain from one subunit and the R3H domain from the other subunit enclose the active site. | 19217398 |
| 2010-01-21 00:00:00 | Solution structures of the cap-binding domain of mouse PARN with and without the m(7)GpppG cap analog reveal a novel cap-binding mode. | 18641416 |
| Type | IDs |
|---|---|
| Synonymous | 1200003I18Rik, DAN |
| Gene |
UniProtKB-ID:
PARN_MOUSE,
A0A0R4J0P6_MOUSE
UniprotKB:
Q8VDG3,
A0A0R4J0P6
UniParc:
UPI000002844F,
UPI0000028B52
EMBL:
AK045181,
BC021899,
AC154564,
AC154607,
AK004572
Ensembl:
ENSMUSG00000022685
KO:
mmu:74108
|
| Nucleutide sequences |
EMBL-CDS:
BAB23382.1,
AAH21899.1,
BAC32249.1
Ensembl_TRS:
ENSMUST00000058884
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000055969
RefSeq:
NP_001345381.1,
XP_006522715.1,
XP_030105165.1,
XP_036016049.1,
NP_001345382.1,
XP_017172634.1,
NP_083037.1
|
| Others |
UniRef100:
UniRef100_Q8VDG3,
UniRef100_A0A0R4J0P6
UniRef90:
UniRef90_Q8VDG3
UniRef50:
UniRef50_O95453
UniGene:
Mm.182350
CCDS:
CCDS37259.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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