| Type | Description |
|---|---|
| Definition | tubulin, beta 2B class IIB |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 12:14:00 | Study shows that loss of Tubb2a or Tubb2b does not impair survival but does lead to relatively mild cortical malformation phenotypes. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases. | 31386652 |
| 2017-07-01 10:11:00 | The data presented here demonstrate that a heterozygous Tubb2b brdp/+ mutation in mice leads to significant spatial learning and memory reductions and conditioned contextual, but not cued, fear deficits. | 27594048 |
| 2016-10-22 12:15:00 | study shows TUBB2B significantly upregulated in melanoma multinucleated giant cells, which indicates that it may play an important role in melanoma metastasis. | 26531888 |
| 2016-05-21 13:03:00 | Study showed that Tubb2b is expressed in Sox2- and Tbr2-positive neuronal progenitors and, at higher levels, in Dcx-positive postmitotic neurons in the developing mouse neocortex | 26105993 |
| 2014-04-26 12:29:00 | Results show that the missense mutation at a highly conserved residue (N247S) in Tubb2b gene represents the most severely affected mouse tubulin phenotype involving neuronal proliferation and survival. | 23727838 |
| Type | IDs |
|---|---|
| Synonymous | 2410129E14Rik, brdp |
| Gene |
UniProtKB-ID:
TBB2B_MOUSE,
B2RSN3_MOUSE
UniprotKB:
Q9CWF2,
B2RSN3
UniParc:
UPI0000024E6E
EMBL:
BC138936,
BC138935,
AK168908,
AK010786
Ensembl:
ENSMUSG00000045136
KO:
mmu:73710
|
| Nucleutide sequences |
EMBL-CDS:
BAB27182.1,
BAE40722.1,
AAI38936.1,
AAI38937.1
Ensembl_TRS:
ENSMUST00000075774
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000075178
RefSeq:
NP_076205.1
|
| Others |
UniRef100:
UniRef100_Q9BVA1
UniRef90:
UniRef90_Q9BVA1
UniRef50:
UniRef50_Q9BVA1
UniGene:
Mm.379227,
Mm.472121
CCDS:
CCDS26445.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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