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73689 Bloc1s2

73689

Bloc1s2

biogenesis of lysosomal organelles complex-1, subunit 2

protein-coding

Mus musculus

基因描述

Type Description
Definition biogenesis of lysosomal organelles complex-1, subunit 2

研究结论

Date Results Publications
2017-11-04 10:37:00 BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates. 27719760
2017-09-16 12:06:00 These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during fetal liver hematopoiesis. 28456747
2015-12-19 11:07:00 SLX2 might get involved in chromosomes segregation during meiosis by interaction with BLOS2. 24870619
2010-06-28 11:07:00 WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells 20308062
2010-01-21 00:00:00 Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models 15102850

名称对应

Type IDs
Synonymous 2410089B13Rik, BLOS2, Bloc1s2a
Gene
UniProtKB-ID: BL1S2_MOUSE
UniprotKB: Q9CWG9
UniParc: UPI0000022572
EMBL: AL928960, AK010745, BC065806
Ensembl: ENSMUSG00000057506
KO: mmu:73689
Nucleutide sequences
EMBL-CDS: BAB27155.1, AAH65806.1
Ensembl_TRS: ENSMUST00000079033
Protein sequencees
Ensembl_PRO: ENSMUSP00000078042
RefSeq: XP_011245671.1, NP_082883.1
Others
UniRef100: UniRef100_Q9CWG9
UniRef90: UniRef90_Q9CWG9
UniRef50: UniRef50_Q6QNY1
UniGene: Mm.124685
CCDS: CCDS50445.1

全选

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研究热度

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