UGT2B4 - UDP glucuronosyltransferase family 2 member B4-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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7363 UGT2B4

基因描述

Type	Description
Definition	UDP glucuronosyltransferase family 2 member B4

研究结论

Date	Results	Publications
2018-10-20 11:39:00	Clopidogrel carboxylic acid is metabolized mainly by UGT2B7 and UGT2B4 in the liver and by UGT2B17 in the small intestinal wall.	29138287
2017-01-28 11:13:00	UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females.	27282283
2016-02-20 11:05:00	These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity	25948711
2012-08-04 11:18:00	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo	22092298
2012-08-04 10:23:00	The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.	22367021

名称对应

Type	IDs
Synonymous	HLUG25, UDPGT2B4, UDPGTH1, UDPGTh-1, UGT2B11
Gene	UniProtKB-ID: UD2B4_HUMAN UniprotKB: P06133 UniParc: UPI000000087F, UPI0000EE2D3A, UPI00017A7B97 EMBL: AC108078, CH471057, AF064200, AF081793, AF135416, Y00317, AK292748, AJ005162, BC026264, DQ520733, AY529122, AK300084, AC093829 Ensembl: ENSG00000156096 KO: hsa:7363
Nucleutide sequences	EMBL-CDS: BAF85437.1, EAX05591.1, CAA68415.1, CAA06396.1, AAC95002.1, BAG61887.1, AAC32272.1, ABF47107.1, AAH26264.1, AAS47487.1, AAF78145.1 Ensembl_TRS: ENST00000512583, ENST00000305107
Protein sequencees	Ensembl_PRO: ENSP00000421290, ENSP00000305221 RefSeq: NP_001284545.1, NP_001284544.1, NP_066962.2
Others	UniRef100: UniRef100_P06133 UniRef90: UniRef90_P06133 UniRef50: UniRef50_Q62789 UniGene: Hs.285887 CCDS: CCDS75137.1, CCDS43234.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
29138287	Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions^â. Drug Metab. Dispos. HelinÃ¤ Kahma , Anne M Filppula , Mikko Neuvonen , E Katriina Tarkiainen , Aleksi Tornio , Mikko T Holmberg , Matti K Itkonen , Moshe Finel , Pertti J Neuvonen , Mikko Niemi , Janne T Backman	2018-02-01	-
27282283	UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females. Gene Anna Yermachenko , Volodymyr Dvornyk	2016-09-15	-
25948711	Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. Drug Metab. Dispos. Kathleen G Barrett , Hailin Fang , Daniela Cukovic , Alan A Dombkowski , Thomas A Kocarek , Melissa Runge-Morris	2015-07-01	UGT2B4, PAPSS1
22367021	High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk. Int. J. Oncol. Polat Dura , Jody Salomon , Rene H M Te Morsche , Hennie M J Roelofs , Jon O Kristinsson , Theo Wobbes , Ben J M Witteman , Adriaan C I T L Tan , Joost P H Drenth , Wilbert H M Peters	2012-06-01	UGT1A8, UGT1A1, UGT2B4
22092298	Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects. Br J Clin Pharmacol Eloise A Gelston , Janet K Coller , Olga V Lopatko , Heather M James , Helmut Schmidt , Jason M White , Andrew A Somogyi	2012-05-01	CYP2D6, UGT2B4, UGT2B7
21660508	A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk. Hum. Genet. Chang Sun , Dezheng Huo , Catherine Southard , Barbara Nemesure , Anselm Hennis , M Cristina Leske , Suh-Yuh Wu , David B Witonsky , Olufunmilayo I Olopade , Anna Di Rienzo	2011-12-01	-
21988832	Toward an understanding of the protein interaction network of the human liver. Mol. Syst. Biol. Jian Wang , Keke Huo , Lixin Ma , Liujun Tang , Dong Li , Xiaobi Huang , Yanzhi Yuan , Chunhua Li , Wei Wang , Wei Guan , Hui Chen , Chaozhi Jin , Juncheng Wei , Wanqiao Zhang , Yongsheng Yang , Qiongming Liu , Ying Zhou , Cuili Zhang , Zhihao Wu , Wangxiang Xu , Ying Zhang , Tao Liu , Donghui Yu , Yaping Zhang , Liang Chen , Dewu Zhu , Xing Zhong , Lixin Kang , Xiang Gan , Xiaolan Yu , Qi Ma , Jing Yan , Li Zhou , Zhongyang Liu , Yunping Zhu , Tao Zhou , Fuchu He , Xiaoming Yang	2011-10-11	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
20734064	A large-scale candidate gene association study of age at menarche and age at natural menopause. Hum. Genet. Chunyan He , Peter Kraft , Daniel I Chasman , Julie E Buring , Constance Chen , Susan E Hankinson , Guillaume ParÃ© , Stephen Chanock , Paul M Ridker , David J Hunter	2010-11-01	PPIF, GDF11, FST, LEFTY1, SLC12A7, CGA, ADAMTS13, SLC2A6, CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB1, CHRNB2, CHRNB3, CHRNB4, CHRND, CHRNE, CHRNG, CCR3, NLRP5, CNR1, PROKR2, ACVR1C, COMT, CRHR1, CRHR2, MAPK14, EME1, GDF7, SLC2A12, ADRB2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, GRK3, CYP3A4, CYP11A1, CYP17A1, CYP19A1, DBH, ACE, CITED4, DDC, AKR1C2, DIAPH2, DRD1, DRD2, DRD3, DRD5, AGT, ECT2, EML1, AKT1, ESR1, ESR2, F2, F5, ALDH1B1, FGFR1, FMO1, FMO3, FMR1, AFF2, LEPROTL1, FSHB, FSHR, ANKK1, PCSK9, GABRB2, GALT, FGFR1OP2, GDF1, GDF2, MSTN, GDF9, GDF10, AMH, GH1, GHR, GHRH, AMHR2, GHRHR, BMP10, GNB3, GNRH1, GNRHR, MCHR1, NR3C1, HBE1, HIVEP1, AIRE, HSD3B1, HSD3B2, HSD17B1
20628086	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Diabetes Care Swneke D Bailey , Changchun Xie , Ron Do , Alexandre Montpetit , Rafael Diaz , Viswanathan Mohan , Bernard Keavney , Salim Yusuf , Hertzel C Gerstein , James C Engert , Sonia Anand , DREAM investigators	2010-10-01	-

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