UGCG - UDP-glucose ceramide glucosyltransferase-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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7357 UGCG

基因描述

Type	Description
Definition	UDP-glucose ceramide glucosyltransferase

研究结论

Date	Results	Publications
2021-04-17 13:17:00	Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.	32980536
2020-12-05 12:59:00	UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells.	32424263
2020-11-21 13:16:00	UGCG influences glutamine metabolism of breast cancer cells.	31666638
2019-03-30 11:53:00	the GCS inhibitor lucerastat provides a viable mechanism to reduce Gb3 accumulation and lysosome volume, suitable for all Fabry patients regardless of genotype	29982630
2019-03-23 11:34:00	findings suggest that complex formation between SMS1 and GCS is part of a critical mechanism controlling the metabolic fate of Cer in the Golgi.	30242129

名称对应

Type	IDs
Synonymous	GCS, GLCT1
Gene	UniProtKB-ID: CEGT_HUMAN, A0A024R157_HUMAN UniprotKB: Q16739, A0A024R157 UniParc: UPI0000052740 EMBL: CH471105, AL442066, D50840, AK314847, BC038711 Ensembl: ENSG00000148154 KO: hsa:7357
Nucleutide sequences	EMBL-CDS: BAG37364.1, BAA09451.1, AAH38711.1, EAW59091.1, EAW59092.1 Gene_ORFName: hCG_27600 Ensembl_TRS: ENST00000374279
Protein sequencees	Ensembl_PRO: ENSP00000363397 RefSeq: XP_016870596.1, XP_005252243.1, NP_003349.1
Others	UniRef100: UniRef100_Q16739 UniRef90: UniRef90_Q16739 UniRef50: UniRef50_Q16739 UniGene: Hs.304249, Hs.593014 CCDS: CCDS6782.1

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
32980536	Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide. Biochim Biophys Acta Mol Cell Biol Lipids Takuya Honda , Kaisei Motoyoshi , Junya Kasahara , Kazuyuki Yamagata , Hiromasa Takahashi , Hiroyuki Nakamura , Toshihiko Murayama	2021-01-01	-
32424263	UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells. Sci Rep Nina SchÃ¶mel , Lisa Gruber , Stephanie J Alexopoulos , Sandra Trautmann , Ellen M Olzomer , Frances L Byrne , Kyle L Hoehn , Robert Gurke , Dominique Thomas , Nerea FerreirÃ³s , Gerd Geisslinger , Marthe-Susanna Wegner	2020-05-18	-
31666638	UGCG influences glutamine metabolism of breast cancer cells. Sci Rep Nina SchÃ¶mel , Sarah E Hancock , Lisa Gruber , Ellen M Olzomer , Frances L Byrne , Divya Shah , Kyle L Hoehn , Nigel Turner , Sabine GrÃ¶sch , Gerd Geisslinger , Marthe-Susanna Wegner	2019-10-30	-
30242129	Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels. J Biol Chem Yasuhiro Hayashi , Yoko Nemoto-Sasaki , Naoki Matsumoto , Kotaro Hama , Takashi Tanikawa , Saori Oka , Tadaaki Saeki , Tatsuya Kumasaka , Takanori Koizumi , Seisuke Arai , Ikuo Wada , Kazuaki Yokoyama , Takayuki Sugiura , Atsushi Yamashita	2018-11-09	-
29982630	Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types. Hum Mol Genet R W D Welford , A MÃ¼hlemann , M Garzotti , V Rickert , P M A Groenen , O Morand , N ÃÃ§eyler , M R Probst	2018-10-01	-
29676528	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. FEBS J. Richa Khanna , Vidhya Krishnamoorthy , Veena K Parnaik	2018-06-01	-
29409484	The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1). BMC Cancer Marthe-Susanna Wegner , Lisa Gruber , Peter Mattjus , Gerd Geisslinger , Sabine GrÃ¶sch	2018-02-06	-
29117863	RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. BMC Biol Nila Roy Choudhury , Gregory Heikel , Maryia Trubitsyna , Peter Kubik , Jakub Stanislaw Nowak , Shaun Webb , Sander Granneman , Christos Spanos , Juri Rappsilber , Alfredo Castello , Gracjan Michlewski	2017-11-08	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
27191984	Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer. Oncotarget Jiannan Liu , Xiaofang Zhang , Aina Liu , Daoping Zhang , Yi Su , Ying Liu , Dong You , Leilei Yuan , Xiangshuo Kong , Xiaodan Wang , Ping Sun	2016-05-13	-

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