| Type | Description |
|---|---|
| Definition | complement C9 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 11:01:00 | Five novel rare genetic variants (p.M45L, p.F62S, p.G126R, p.T170I and p.A529T) in C9 in age-related macular degeneration patients. Those genetic variants affect only the secretion and polymerization of C9, without influencing its classical lytic activity. | 29767720 |
| 2018-11-17 11:56:00 | The data supports the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in retinal pigment epithelial cells. | 30090015 |
| 2016-08-13 11:57:00 | Serum-expressed apolipoprotein B-100 protein, C9 Complement, and gelsolin can be used for differential diagnosis of Barrertts esophagus and adenocarcinoma of esophagus. | 26404905 |
| 2016-08-06 10:38:00 | Patients with advanced atrophic AMD carried these rare variants more frequently than patients with neovascular AMD (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04). | 26767664 |
| 2016-01-16 11:12:00 | Complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. | 25735751 |
| Type | IDs |
|---|---|
| Synonymous | ARMD15, C9D |
| Gene |
UniProtKB-ID:
CO9_HUMAN
UniprotKB:
P02748
UniParc:
UPI0000001065
EMBL:
Y08549,
Y08551,
J02833,
Y08548,
Y08552,
Y08554,
Y08547,
X02176,
BC020721,
Y08546,
Y08550,
Y08545,
Y08553,
K02766
Ensembl:
ENSG00000113600
KO:
hsa:735
|
| Nucleutide sequences |
EMBL-CDS:
AAA51889.1,
CAA26117.1,
CAA69849.1,
AAH20721.1,
AAA51890.1
Ensembl_TRS:
ENST00000263408
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000263408
RefSeq:
NP_001728.1
|
| Others |
UniRef100:
UniRef100_P02748
UniRef90:
UniRef90_P02748
UniRef50:
UniRef50_P02748
UniGene:
Hs.654443
CCDS:
CCDS3929.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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